Poly(ADP-ribose): An organizer of cellular architecture

Research output: Contribution to journalComment/debatepeer-review

Abstract

Distinct properties of poly(ADP-ribose)-including its structural diversity, nucleation potential, and low complexity, polyvalent, highly charged nature-could contribute to organizing cellular architectures. Emergent data indicate that poly(ADP-ribose) aids in the formation of nonmembranous structures, such as DNA repair foci, spindle poles, and RNA granules. Informatics analyses reported here show that RNA granule proteins enriched for low complexity regions, which aid self-assembly, are preferentially modified by poly(ADP-ribose), indicating how poly(ADPribose) could direct cellular organization.

Original languageEnglish (US)
Pages (from-to)613-619
Number of pages7
JournalJournal of Cell Biology
Volume205
Issue number5
DOIs
StatePublished - 2014

ASJC Scopus subject areas

  • Cell Biology

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