Poly-arginine conjugated triarylmethyl radical as intracellular spin label

Benoit Driesschaert, Andrey A. Bobko, Timothy D. Eubank, Alexandre Samouilov, Valery V. Khramtsov, Jay L. Zweier

Research output: Contribution to journalArticlepeer-review


Stable triarylmethyl radicals are ideal spin labels used for biomedical electron paramagnetic resonance applications. Previously reported structures exhibit polar charged functions for water solubilization preventing them from crossing the cell membrane. We report the synthesis of a triarylmethyl radical conjugated to poly-arginine peptide allowing intracellular delivery of the paramagnetic label.

Original languageEnglish (US)
Pages (from-to)1742-1744
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Issue number7
StatePublished - 2016
Externally publishedYes


  • Cyclic voltammetry
  • EPR
  • Poly-arginine
  • Radical
  • TAM

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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