Poly (ADP-ribose) (PAR)-dependent cell death in neurodegenerative diseases

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Disruption of cellular functions with aging-induced accumulation of neuronal stressors causes cell death which is a common feature of neurodegenerative diseases. Studies in a variety of neurodegenerative disease models demonstrate that poly (ADP-ribose) (PAR)-dependent cell death, also named parthanatos, is responsible for neuronal loss in neurological diseases, such as Parkinson's disease (PD), Alzheimer's disease (AD), Huntington's disease (HD) and amyotrophic lateral sclerosis (ALS). Parthanatos has distinct features that differ from caspase-dependent apoptosis, necrosis or autophagic cell death. Parthanatos can be triggered by the accumulation of PAR due to overactivation of PAR polymerase-1 (PARP-1). Excess PAR, induces the mitochondrial release apoptosis-inducing factor (AIF), which binds to macrophage migration inhibitory factor (MIF) carrying MIF into the nucleus where it cleaves genomic DNA into large fragments. In this review, we will discuss the molecular mechanisms of parthanatos and their role in neurodegenerative diseases. Furthermore, we will discuss promising therapeutic interventions within the pathological PAR signaling cascade that could be designed to halt the progression of neurodegeneration.

Original languageEnglish (US)
Title of host publicationInternational Review of Cell and Molecular Biology
EditorsJohan K.E. Spetz, Lorenzo Galluzzi
PublisherElsevier Inc.
Pages1-29
Number of pages29
ISBN (Print)9780128201350
DOIs
StatePublished - 2020

Publication series

NameInternational Review of Cell and Molecular Biology
Volume353
ISSN (Print)1937-6448

Keywords

  • AIF
  • Cell death
  • MIF
  • Neurodegenerative disease
  • PAR
  • PARP-1
  • Parthanatos
  • Poly (ADP-ribose)

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'Poly (ADP-ribose) (PAR)-dependent cell death in neurodegenerative diseases'. Together they form a unique fingerprint.

Cite this