Polo-like kinase 4 shapes Up

Michelle S. Levine, Andrew J. Holland

Research output: Contribution to journalShort survey

Abstract

Polo-like kinase 4 (Plk4) is a master regulator of centriole duplication and targets to centrioles through the association of its cryptic polo box domain with centriole receptors. In this issue of Structure, Shimanovskaya and colleagues unveil a new dimeric architecture of Plk4's cryptic polo box that reveals a conserved mechanism for centriole targeting of the kinase.

Original languageEnglish (US)
Pages (from-to)1071-1073
Number of pages3
JournalStructure
Volume22
Issue number8
DOIs
StatePublished - Aug 5 2014

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

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