Polo-like kinase 4 shapes Up

Michelle S. Levine; Andrew J. Holland

doi:10.1016/j.str.2014.07.004

Polo-like kinase 4 shapes Up

Michelle S. Levine, Andrew J. Holland

School of Medicine

Research output: Contribution to journal › Short survey

Abstract

Polo-like kinase 4 (Plk4) is a master regulator of centriole duplication and targets to centrioles through the association of its cryptic polo box domain with centriole receptors. In this issue of Structure, Shimanovskaya and colleagues unveil a new dimeric architecture of Plk4's cryptic polo box that reveals a conserved mechanism for centriole targeting of the kinase.

Original language	English (US)
Pages (from-to)	1071-1073
Number of pages	3
Journal	Structure
Volume	22
Issue number	8
DOIs	https://doi.org/10.1016/j.str.2014.07.004
State	Published - Aug 5 2014

ASJC Scopus subject areas

Structural Biology
Molecular Biology

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10.1016/j.str.2014.07.004

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Levine, M. S., & Holland, A. J. (2014). Polo-like kinase 4 shapes Up. Structure, 22(8), 1071-1073. https://doi.org/10.1016/j.str.2014.07.004

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