Poliovirus excretion in Guatemalan adults and children with HIV infection and children with cancer

Edwin J. Asturias; Carlos F. Grazioso; Sandra Luna-Fineman; Olga Torres; Neal A. Halsey

doi:10.1016/j.biologicals.2006.03.002

Poliovirus excretion in Guatemalan adults and children with HIV infection and children with cancer

Edwin J. Asturias, Carlos F. Grazioso, Sandra Luna-Fineman, Olga Torres, Neal A. Halsey

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

More than 20 patients with persistent poliovirus infections have been identified and reported to WHO. To date, almost all of these patients have had B-cell immune deficiency disorders. Since there are limited data on patients with HIV infection who have received oral poliovirus vaccine (OPV), we studied adults and children to determine if persons with acquired immunodeficiency due to HIV infection or cancer chemotherapy in a developing country setting had prolonged excretion of polioviruses. Stool samples from 94 HIV-infected children and 101 adults and 50 children surviving cancer in Guatemala City were cultured for polioviruses. No polioviruses were detected in any of the 195 persons with HIV infection or the 50 with cancer. The evidence from this and other studies indicates that the persistent poliovirus excretion in HIV-infected individuals is an unlikely event.

Original language	English (US)
Pages (from-to)	109-112
Number of pages	4
Journal	Biologicals
Volume	34
Issue number	2
DOIs	https://doi.org/10.1016/j.biologicals.2006.03.002
State	Published - Jun 2006

Keywords

B-cell immunity
Cancer chemotherapy
HIV infection
Immunodeficiency
Poliovirus excretion
Poliovirus infection

ASJC Scopus subject areas

Biotechnology
Bioengineering
Applied Microbiology and Biotechnology
General Immunology and Microbiology
Pharmacology

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title = "Poliovirus excretion in Guatemalan adults and children with HIV infection and children with cancer",

abstract = "More than 20 patients with persistent poliovirus infections have been identified and reported to WHO. To date, almost all of these patients have had B-cell immune deficiency disorders. Since there are limited data on patients with HIV infection who have received oral poliovirus vaccine (OPV), we studied adults and children to determine if persons with acquired immunodeficiency due to HIV infection or cancer chemotherapy in a developing country setting had prolonged excretion of polioviruses. Stool samples from 94 HIV-infected children and 101 adults and 50 children surviving cancer in Guatemala City were cultured for polioviruses. No polioviruses were detected in any of the 195 persons with HIV infection or the 50 with cancer. The evidence from this and other studies indicates that the persistent poliovirus excretion in HIV-infected individuals is an unlikely event.",

keywords = "B-cell immunity, Cancer chemotherapy, HIV infection, Immunodeficiency, Poliovirus excretion, Poliovirus infection",

author = "Asturias, {Edwin J.} and Grazioso, {Carlos F.} and Sandra Luna-Fineman and Olga Torres and Halsey, {Neal A.}",

note = "Funding Information: The authors thank the participating children and parents, Irma Flores-Maldonado for recruitment and sample collection, Roger Gil-Cordon for enrolment of children at IGSS, Evelyn Piedrasanta for viral cultures, Ellyn Ogden and Hamidah Hussain for administrative support, and Tina Proveaux for assistance with manuscript preparation. This work was supported by a grant from the United States Agency for International Development.",

year = "2006",

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doi = "10.1016/j.biologicals.2006.03.002",

language = "English (US)",

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pages = "109--112",

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AU - Asturias, Edwin J.

AU - Grazioso, Carlos F.

AU - Luna-Fineman, Sandra

AU - Torres, Olga

AU - Halsey, Neal A.

N1 - Funding Information: The authors thank the participating children and parents, Irma Flores-Maldonado for recruitment and sample collection, Roger Gil-Cordon for enrolment of children at IGSS, Evelyn Piedrasanta for viral cultures, Ellyn Ogden and Hamidah Hussain for administrative support, and Tina Proveaux for assistance with manuscript preparation. This work was supported by a grant from the United States Agency for International Development.

PY - 2006/6

Y1 - 2006/6

N2 - More than 20 patients with persistent poliovirus infections have been identified and reported to WHO. To date, almost all of these patients have had B-cell immune deficiency disorders. Since there are limited data on patients with HIV infection who have received oral poliovirus vaccine (OPV), we studied adults and children to determine if persons with acquired immunodeficiency due to HIV infection or cancer chemotherapy in a developing country setting had prolonged excretion of polioviruses. Stool samples from 94 HIV-infected children and 101 adults and 50 children surviving cancer in Guatemala City were cultured for polioviruses. No polioviruses were detected in any of the 195 persons with HIV infection or the 50 with cancer. The evidence from this and other studies indicates that the persistent poliovirus excretion in HIV-infected individuals is an unlikely event.

AB - More than 20 patients with persistent poliovirus infections have been identified and reported to WHO. To date, almost all of these patients have had B-cell immune deficiency disorders. Since there are limited data on patients with HIV infection who have received oral poliovirus vaccine (OPV), we studied adults and children to determine if persons with acquired immunodeficiency due to HIV infection or cancer chemotherapy in a developing country setting had prolonged excretion of polioviruses. Stool samples from 94 HIV-infected children and 101 adults and 50 children surviving cancer in Guatemala City were cultured for polioviruses. No polioviruses were detected in any of the 195 persons with HIV infection or the 50 with cancer. The evidence from this and other studies indicates that the persistent poliovirus excretion in HIV-infected individuals is an unlikely event.

KW - B-cell immunity

KW - Cancer chemotherapy

KW - HIV infection

KW - Immunodeficiency

KW - Poliovirus excretion

KW - Poliovirus infection

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Poliovirus excretion in Guatemalan adults and children with HIV infection and children with cancer

Abstract

Keywords

ASJC Scopus subject areas

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