Abstract
Capillary endothelial cells isolated from rat brain exhibit Na +-dependent uptake of the neutral amino acid analog α-(methylamino)isobutyric acid. Since studies in vivo demonstrate that this transport system is not present on the blood side of brain capillaries we conclude that Na+-dependent neutral amino acid transport is located on the brain side. Therefore, the luminal plasma membrane and the anti-luminal plasma membrane appear to be functionally distinct. This polarity should permit brain capillary endothelial cells to actively regulate the internal milieu of the brain.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 225-226 |
| Number of pages | 2 |
| Journal | Science |
| Volume | 202 |
| Issue number | 4364 |
| DOIs | |
| State | Published - 1978 |
| Externally published | Yes |
ASJC Scopus subject areas
- General