Polarity of the blood-brain barrier: Neutral amino acid transport into isolated brain capillaries

A. Lorris Betz, Gary W. Goldstein

Research output: Contribution to journalArticlepeer-review

Abstract

Capillary endothelial cells isolated from rat brain exhibit Na +-dependent uptake of the neutral amino acid analog α-(methylamino)isobutyric acid. Since studies in vivo demonstrate that this transport system is not present on the blood side of brain capillaries we conclude that Na+-dependent neutral amino acid transport is located on the brain side. Therefore, the luminal plasma membrane and the anti-luminal plasma membrane appear to be functionally distinct. This polarity should permit brain capillary endothelial cells to actively regulate the internal milieu of the brain.

Original languageEnglish (US)
Pages (from-to)225-226
Number of pages2
JournalScience
Volume202
Issue number4364
DOIs
StatePublished - Jan 1 1978
Externally publishedYes

ASJC Scopus subject areas

  • General

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