TY - JOUR
T1 - Point-of-use rapid detection of sars-cov-2
T2 - Nanotechnology-enabled solutions for the covid-19 pandemic
AU - Rabiee, Navid
AU - Bagherzadeh, Mojtaba
AU - Ghasemi, Amir
AU - Zare, Hossein
AU - Ahmadi, Sepideh
AU - Fatahi, Yousef
AU - Dinarvand, Rassoul
AU - Rabiee, Mohammad
AU - Ramakrishna, Seeram
AU - Shokouhimehr, Mohammadreza
AU - Varma, Rajender S.
N1 - Funding Information:
Acknowledgments: The authors want to acknowledge support from Sharif University of Technology, Tehran, Iran. The supports by the Research Council of the Sharif University of Technology is gratefully acknowledged.
Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2020/7/2
Y1 - 2020/7/2
N2 - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused the COVID-19 pandemic that has been spreading around the world since December 2019. More than 10 million affected cases and more than half a million deaths have been reported so far, while no vaccine is yet available as a treatment. Considering the global healthcare urgency, several techniques, including whole genome sequencing and computed tomography imaging have been employed for diagnosing infected people. Considerable efforts are also directed at detecting and preventing different modes of community transmission. Among them is the rapid detection of virus presence on different surfaces with which people may come in contact. Detection based on non-contact optical techniques is very helpful in managing the spread of the virus, and to aid in the disinfection of surfaces. Nanomaterial-based methods are proven suitable for rapid detection. Given the immense need for science led innovative solutions, this manuscript critically reviews recent literature to specifically illustrate nano-engineered effective and rapid solutions. In addition, all the different techniques are critically analyzed, compared, and contrasted to identify the most promising methods. Moreover, promising research ideas for high accuracy of detection in trace concentrations, via color change and light-sensitive nanostructures, to assist fingerprint techniques (to identify the virus at the contact surface of the gas and solid phase) are also presented.
AB - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused the COVID-19 pandemic that has been spreading around the world since December 2019. More than 10 million affected cases and more than half a million deaths have been reported so far, while no vaccine is yet available as a treatment. Considering the global healthcare urgency, several techniques, including whole genome sequencing and computed tomography imaging have been employed for diagnosing infected people. Considerable efforts are also directed at detecting and preventing different modes of community transmission. Among them is the rapid detection of virus presence on different surfaces with which people may come in contact. Detection based on non-contact optical techniques is very helpful in managing the spread of the virus, and to aid in the disinfection of surfaces. Nanomaterial-based methods are proven suitable for rapid detection. Given the immense need for science led innovative solutions, this manuscript critically reviews recent literature to specifically illustrate nano-engineered effective and rapid solutions. In addition, all the different techniques are critically analyzed, compared, and contrasted to identify the most promising methods. Moreover, promising research ideas for high accuracy of detection in trace concentrations, via color change and light-sensitive nanostructures, to assist fingerprint techniques (to identify the virus at the contact surface of the gas and solid phase) are also presented.
KW - COVID-19
KW - Nanoparticles
KW - Nanotechnology
KW - Point-of-use
KW - Rapid detection of virus
KW - SARS-CoV-2
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U2 - 10.3390/ijms21145126
DO - 10.3390/ijms21145126
M3 - Review article
C2 - 32698479
AN - SCOPUS:85088161953
VL - 21
SP - 1
EP - 23
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
SN - 1661-6596
IS - 14
M1 - 5126
ER -