Point-of-care urine ethyl glucuronide testing to detect alcohol use among HIV-hepatitis B virus coinfected adults in Zambia

Michael J. Vinikoor, Zude Zyambo, Monde Muyoyeta, Geetanjali Chander, Michael S. Saag, Karen Cropsey

Research output: Contribution to journalArticle

Abstract

In an HIV-hepatitis B virus (HIV-HBV) coinfection cohort in Zambia, we piloted a qualitative point-of-care (POC) test for urine Ethyl glucuronide (uEtG), assessed concordance between uEtG and alcohol use disorders identification testconsumption (AUDIT-C), and identified epidemiological factors associated with underreporting (defined as uEtG-positivity with last reported drink > 7 days prior). Among 211 participants (40.8% women), there were 44 (20.8%) lifetime abstainers, 32 (15.2%) former drinkers, and 135 (64.0%) current drinkers, including 106 (50.2%) with unhealthy drinking per AUDITC. Eighty-seven (41.2%) were uEtG-positive including 64 of 65 (98.5%) who drank ≤ 3 days prior and 17 of 134 (12.7%) underreported, all of whom admitted to recent drinking when results were discussed. uEtG was moderately concordant with AUDIT-C. Past drinking (versus lifetime abstinence) and longer time on antiretrovirals (≥ 12 months) were associated with underreporting. These data support further use of POC alcohol biomarkers in HIV and hepatitis research and clinical settings.

Original languageEnglish (US)
Pages (from-to)2334-2339
Number of pages6
JournalAIDS and behavior
Volume22
Issue number7
DOIs
StatePublished - Jan 1 2018

Fingerprint

Point-of-Care Systems
Zambia
Hepatitis B virus
Alcohols
HIV
Urine
Drinking
Coinfection
Hepatitis
Ethanol
Biomarkers
ethyl glucuronide
Research

Keywords

  • Africa
  • Alcohol biomarker
  • Alcohol use disorder
  • Ethyl glucuronide
  • Hepatitis B virus
  • HIV/AIDS

ASJC Scopus subject areas

  • Social Psychology
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Cite this

Point-of-care urine ethyl glucuronide testing to detect alcohol use among HIV-hepatitis B virus coinfected adults in Zambia. / Vinikoor, Michael J.; Zyambo, Zude; Muyoyeta, Monde; Chander, Geetanjali; Saag, Michael S.; Cropsey, Karen.

In: AIDS and behavior, Vol. 22, No. 7, 01.01.2018, p. 2334-2339.

Research output: Contribution to journalArticle

Vinikoor, Michael J. ; Zyambo, Zude ; Muyoyeta, Monde ; Chander, Geetanjali ; Saag, Michael S. ; Cropsey, Karen. / Point-of-care urine ethyl glucuronide testing to detect alcohol use among HIV-hepatitis B virus coinfected adults in Zambia. In: AIDS and behavior. 2018 ; Vol. 22, No. 7. pp. 2334-2339.
@article{9bbc19af4c644eabb045cbf53abd0c0b,
title = "Point-of-care urine ethyl glucuronide testing to detect alcohol use among HIV-hepatitis B virus coinfected adults in Zambia",
abstract = "In an HIV-hepatitis B virus (HIV-HBV) coinfection cohort in Zambia, we piloted a qualitative point-of-care (POC) test for urine Ethyl glucuronide (uEtG), assessed concordance between uEtG and alcohol use disorders identification testconsumption (AUDIT-C), and identified epidemiological factors associated with underreporting (defined as uEtG-positivity with last reported drink > 7 days prior). Among 211 participants (40.8{\%} women), there were 44 (20.8{\%}) lifetime abstainers, 32 (15.2{\%}) former drinkers, and 135 (64.0{\%}) current drinkers, including 106 (50.2{\%}) with unhealthy drinking per AUDITC. Eighty-seven (41.2{\%}) were uEtG-positive including 64 of 65 (98.5{\%}) who drank ≤ 3 days prior and 17 of 134 (12.7{\%}) underreported, all of whom admitted to recent drinking when results were discussed. uEtG was moderately concordant with AUDIT-C. Past drinking (versus lifetime abstinence) and longer time on antiretrovirals (≥ 12 months) were associated with underreporting. These data support further use of POC alcohol biomarkers in HIV and hepatitis research and clinical settings.",
keywords = "Africa, Alcohol biomarker, Alcohol use disorder, Ethyl glucuronide, Hepatitis B virus, HIV/AIDS",
author = "Vinikoor, {Michael J.} and Zude Zyambo and Monde Muyoyeta and Geetanjali Chander and Saag, {Michael S.} and Karen Cropsey",
year = "2018",
month = "1",
day = "1",
doi = "10.1007/s10461-018-2030-8",
language = "English (US)",
volume = "22",
pages = "2334--2339",
journal = "AIDS and Behavior",
issn = "1090-7165",
publisher = "Springer New York",
number = "7",

}

TY - JOUR

T1 - Point-of-care urine ethyl glucuronide testing to detect alcohol use among HIV-hepatitis B virus coinfected adults in Zambia

AU - Vinikoor, Michael J.

AU - Zyambo, Zude

AU - Muyoyeta, Monde

AU - Chander, Geetanjali

AU - Saag, Michael S.

AU - Cropsey, Karen

PY - 2018/1/1

Y1 - 2018/1/1

N2 - In an HIV-hepatitis B virus (HIV-HBV) coinfection cohort in Zambia, we piloted a qualitative point-of-care (POC) test for urine Ethyl glucuronide (uEtG), assessed concordance between uEtG and alcohol use disorders identification testconsumption (AUDIT-C), and identified epidemiological factors associated with underreporting (defined as uEtG-positivity with last reported drink > 7 days prior). Among 211 participants (40.8% women), there were 44 (20.8%) lifetime abstainers, 32 (15.2%) former drinkers, and 135 (64.0%) current drinkers, including 106 (50.2%) with unhealthy drinking per AUDITC. Eighty-seven (41.2%) were uEtG-positive including 64 of 65 (98.5%) who drank ≤ 3 days prior and 17 of 134 (12.7%) underreported, all of whom admitted to recent drinking when results were discussed. uEtG was moderately concordant with AUDIT-C. Past drinking (versus lifetime abstinence) and longer time on antiretrovirals (≥ 12 months) were associated with underreporting. These data support further use of POC alcohol biomarkers in HIV and hepatitis research and clinical settings.

AB - In an HIV-hepatitis B virus (HIV-HBV) coinfection cohort in Zambia, we piloted a qualitative point-of-care (POC) test for urine Ethyl glucuronide (uEtG), assessed concordance between uEtG and alcohol use disorders identification testconsumption (AUDIT-C), and identified epidemiological factors associated with underreporting (defined as uEtG-positivity with last reported drink > 7 days prior). Among 211 participants (40.8% women), there were 44 (20.8%) lifetime abstainers, 32 (15.2%) former drinkers, and 135 (64.0%) current drinkers, including 106 (50.2%) with unhealthy drinking per AUDITC. Eighty-seven (41.2%) were uEtG-positive including 64 of 65 (98.5%) who drank ≤ 3 days prior and 17 of 134 (12.7%) underreported, all of whom admitted to recent drinking when results were discussed. uEtG was moderately concordant with AUDIT-C. Past drinking (versus lifetime abstinence) and longer time on antiretrovirals (≥ 12 months) were associated with underreporting. These data support further use of POC alcohol biomarkers in HIV and hepatitis research and clinical settings.

KW - Africa

KW - Alcohol biomarker

KW - Alcohol use disorder

KW - Ethyl glucuronide

KW - Hepatitis B virus

KW - HIV/AIDS

UR - http://www.scopus.com/inward/record.url?scp=85063617773&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85063617773&partnerID=8YFLogxK

U2 - 10.1007/s10461-018-2030-8

DO - 10.1007/s10461-018-2030-8

M3 - Article

C2 - 29336004

AN - SCOPUS:85041365598

VL - 22

SP - 2334

EP - 2339

JO - AIDS and Behavior

JF - AIDS and Behavior

SN - 1090-7165

IS - 7

ER -