Point of care diagnostics for sexually transmitted infections: Perspectives and advances

Charlotte Gaydos, Justin Hardick

Research output: Contribution to journalArticlepeer-review

Abstract

Accurate and inexpensive point-of-care (POC) tests are urgently needed to control sexually transmitted infection epidemics, so that patients can receive immediate diagnoses and treatment. Current POC assays for Chlamydia trachomatis and Neisseria gonorrhoeae perform inadequately and require better assays. Diagnostics for Trichomonas vaginalis rely on wet preparation, with some notable advances. Serological POC assays for syphilis can impact resource-poor settings, with many assays available, but only one available in the U.S. HIV POC diagnostics demonstrate the best performance, with excellent assays available. There is a rapid assay for HSV lesion detection; but no POC serological assays are available. Despite the inadequacy of POC assays for treatable bacterial infections, application of technological advances offers the promise of advancing POC diagnostics for all sexually transmitted infections.

Original languageEnglish (US)
Pages (from-to)657-672
Number of pages16
JournalExpert Review of Anti-Infective Therapy
Volume12
Issue number6
DOIs
StatePublished - Jun 2014

Keywords

  • Chlamydia trachomatis
  • HIV
  • HSV-2
  • Neisseria gonorrhoeae
  • PCR
  • Trichomonas vaginalis
  • point-of-care diagnostics
  • resource-limited settings
  • serology
  • syphilis

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Virology
  • Infectious Diseases

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