Point-of-care Arkansas method for measuring adherence to treatment with isoniazid

Renata L. Guerra, Marcus B. Conde, Anne Efron, Carla Loredo, Gisele Bastos, Richard E. Chaisson, Jonathan E. Golub

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


We evaluated the accuracy of a point-of-care test designed to measure adherence to isoniazid (INH) preventive therapy in a hospital setting in Rio de Janeiro, Brazil. Patients on treatment with daily INH and patients not receiving INH were included. Sensitivity and specificity of the test were 84%/98% at the first minute, and 95%/98% at the fifth minute, respectively. Among smokers, sensitivity and specificity was reduced (80%/89% at the fifth minute, respectively), but only 17% smoked. This test accurately detected INH metabolites 24 h following directly observed INH intake, though sensitivity and specificity may be compromised by tobacco smoke exposure.

Original languageEnglish (US)
Pages (from-to)754-757
Number of pages4
JournalRespiratory Medicine
Issue number5
StatePublished - May 2010


  • Adherence
  • Arkansas method
  • Isoniazid
  • Latent tuberculosis infection

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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