Point-of-care antimicrobial coating protects orthopaedic implants from bacterial challenge

Weixian Xi; Vishal Hegde; Stephen D. Zoller; Howard Y. Park; Christopher M. Hart; Takeru Kondo; Christopher D. Hamad; Yan Hu; Amanda H. Loftin; Daniel O. Johansen; Zachary Burke; Samuel Clarkson; Chad Ishmael; Kellyn Hori; Zeinab Mamouei; Hiroko Okawa; Ichiro Nishimura; Nicholas M. Bernthal; Tatiana Segura

doi:10.1038/s41467-021-25383-z

Point-of-care antimicrobial coating protects orthopaedic implants from bacterial challenge

Weixian Xi, Vishal Hegde, Stephen D. Zoller, Howard Y. Park, Christopher M. Hart, Takeru Kondo, Christopher D. Hamad, Yan Hu, Amanda H. Loftin, Daniel O. Johansen, Zachary Burke, Samuel Clarkson, Chad Ishmael, Kellyn Hori, Zeinab Mamouei, Hiroko Okawa, Ichiro Nishimura, Nicholas M. Bernthal, Tatiana Segura

Research output: Contribution to journal › Article › peer-review

Abstract

Implant related infections are the most common cause of joint arthroplasty failure, requiring revision surgeries and a new implant, resulting in a cost of $8.6 billion annually. To address this problem, we created a class of coating technology that is applied in the operating room, in a procedure that takes less than 10 min, and can incorporate any desired antibiotic. Our coating technology uses an in situ coupling reaction of branched poly(ethylene glycol) and poly(allyl mercaptan) (PEG-PAM) polymers to generate an amphiphilic polymeric coating. We show in vivo efficacy in preventing implant infection in both post-arthroplasty infection and post-spinal surgery infection mouse models. Our technology displays efficacy with or without systemic antibiotics, the standard of care. Our coating technology is applied in a clinically relevant time frame, does not require modification of implant manufacturing process, and does not change the implant shelf life.

Original language	English (US)
Article number	5473
Journal	Nature communications
Volume	12
Issue number	1
DOIs	https://doi.org/10.1038/s41467-021-25383-z
State	Published - Dec 1 2021
Externally published	Yes

ASJC Scopus subject areas

General Chemistry
General Biochemistry, Genetics and Molecular Biology
General Physics and Astronomy

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Xi, W., Hegde, V., Zoller, S. D., Park, H. Y., Hart, C. M., Kondo, T., Hamad, C. D., Hu, Y., Loftin, A. H., Johansen, D. O., Burke, Z., Clarkson, S., Ishmael, C., Hori, K., Mamouei, Z., Okawa, H., Nishimura, I., Bernthal, N. M., & Segura, T. (2021). Point-of-care antimicrobial coating protects orthopaedic implants from bacterial challenge. Nature communications, 12(1), Article 5473. https://doi.org/10.1038/s41467-021-25383-z

Xi, W, Hegde, V, Zoller, SD, Park, HY, Hart, CM, Kondo, T, Hamad, CD, Hu, Y, Loftin, AH, Johansen, DO, Burke, Z, Clarkson, S, Ishmael, C, Hori, K, Mamouei, Z, Okawa, H, Nishimura, I, Bernthal, NM & Segura, T 2021, 'Point-of-care antimicrobial coating protects orthopaedic implants from bacterial challenge', Nature communications, vol. 12, no. 1, 5473. https://doi.org/10.1038/s41467-021-25383-z

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abstract = "Implant related infections are the most common cause of joint arthroplasty failure, requiring revision surgeries and a new implant, resulting in a cost of $8.6 billion annually. To address this problem, we created a class of coating technology that is applied in the operating room, in a procedure that takes less than 10 min, and can incorporate any desired antibiotic. Our coating technology uses an in situ coupling reaction of branched poly(ethylene glycol) and poly(allyl mercaptan) (PEG-PAM) polymers to generate an amphiphilic polymeric coating. We show in vivo efficacy in preventing implant infection in both post-arthroplasty infection and post-spinal surgery infection mouse models. Our technology displays efficacy with or without systemic antibiotics, the standard of care. Our coating technology is applied in a clinically relevant time frame, does not require modification of implant manufacturing process, and does not change the implant shelf life.",

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AU - Johansen, Daniel O.

AU - Burke, Zachary

AU - Clarkson, Samuel

AU - Ishmael, Chad

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AU - Mamouei, Zeinab

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AU - Bernthal, Nicholas M.

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Point-of-care antimicrobial coating protects orthopaedic implants from bacterial challenge

Abstract

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