Poikilodermatous mycosis fungoides

Bradley Bloom, Shari Marchbein, Max Fischer, Hideko Kamino, Rishi Patel, Jo Ann latkowski

Research output: Contribution to journalArticle

Abstract

Poikilodermatous mycosis fungoides (MF) is a variant of MF, formerly referred to as poikiloderma vasculare atrophicans. The lesions are classically characterized by large plaques of hypopigmentation and hyperpigmentation with atrophy and telangiectases. The plaques may be asymptomatic or mildly pruritic and typically involve the major flexural areas and trunk. Poikilodermatous MF has an early stage (IA-IIA) at diagnosis and a male predominance. Poikilodermatous MF shows an atypical T-cell infiltrate in the papillary dermis with evidence of epidermotropism, epidermal atrophy, dilated blood vessels in the dermis, melanophages, and melanin incontinence. Recent studies suggest a predominance of a CD8+, CD4- immunophenotype. Treatment modalities are similar to classic MF with phototherapy being the most common first-line therapy. Poikilodermatous MF has an excellent prognosis.

Original languageEnglish (US)
Number of pages1
JournalDermatology Online Journal
Volume18
Issue number12
StatePublished - Dec 1 2012

ASJC Scopus subject areas

  • Dermatology

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