Abstract
Summary: Renal injury resulting from obesity is a growing concern caused by the global obesity epidemic. We discuss the glomerular structure, obesity-related glomerular changes, and diagnostic pathologic criteria for obesity-related glomerulopathy. The three main hypothesized mechanisms of podocyte injury are mechanical stress on the podocytes, metabolic derangement, and genetic/molecular factors. Weight loss, renin-angiotensin-aldosterone system inhibitors, and improved insulin resistance may slow the progression. A more comprehensive understanding of obesity-related glomerulopathy will help in developing more effective therapies.
Original language | English (US) |
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Pages (from-to) | 307-317 |
Number of pages | 11 |
Journal | Seminars in Nephrology |
Volume | 41 |
Issue number | 4 |
DOIs | |
State | Published - Jul 2021 |
Keywords
- Obesity
- actin cytoskeleton
- focal segmental glomerulosclerosis
- glomerulus
- nephrotic syndrome
- obesity-related glomerulopathy
- podocytes
- podocytopathy
- proteinuria
ASJC Scopus subject areas
- Nephrology