Pneumonia in the immunocompromised child

Walter T. Hughes

Research output: Contribution to journalArticlepeer-review


Certain types and causes of pneumonia are unique to the immunocompromised host. The most frequent causes are cytomegalovirus, Pneumocystis carinii, varicella zoster virus, Candida species and Aspergillus species. Lymphoid interstitial pneumonia has recently been recognized in children with the acquired immunodeficiency syndrome. With the exception of varicella-zoster pneumonitis, an invasive procedure, such as open lung biopsy, is required to establish a definitive diagnosis. Infrequent causes of pneumonitis in immunocompromised children include Toxoplasma gondii; Cryptosporidium; Herpes simplex: adenovirus, gram-negative bacillary infections (Pseudomonas aeruginose, Klebsiella pneumonice, Escherichia coli, Legionella pneumophilia); Nocardia spp; zygomycetes, and Cryptococcus neoformans. The discovery of any of the aforementioned pneumonias suggests the patient may have a serious underlying immunodeficiency.

Original languageEnglish (US)
Pages (from-to)177-183
Number of pages7
JournalSeminars in Respiratory Infections
Issue number3
StatePublished - Sep 1987

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Microbiology (medical)

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