TY - JOUR
T1 - Pneumonia and respiratory infections in Down syndrome
T2 - A scoping review of the literature
AU - Santoro, Stephanie L.
AU - Chicoine, Brian
AU - Jasien, Joan M.
AU - Kim, Judy Lu
AU - Stephens, Mary
AU - Bulova, Peter
AU - Capone, George
N1 - Funding Information:
Dr. Stephanie L. Santoro receives research funding from the National Institutes of Health. Dr. Stephanie L. Santoro receives research funding from the LuMind IDSC Down Syndrome Foundation to conduct clinical trials for people with DS and serves on the Professional Advisory Board for the Massachusetts Down Syndrome Congress. The other authors have no conflicts of interest relevant to this article to disclose.
Publisher Copyright:
© 2020 Wiley Periodicals LLC
PY - 2021/1
Y1 - 2021/1
N2 - Pneumonia and respiratory infections impact infants and children with Down syndrome; pneumonia is a leading cause of mortality in adults with Down syndrome. We aimed to review the literature to evaluate gaps and address key questions. A series of key questions were formulated a priori to inform the search strategy and review process; addressed prevalence, severity, etiology, risk factors, preventive methods, screening, and financial costs, potential benefits or harms of screening. Using the National Library of Medicine database, PubMed, detailed literature searches on pneumonia and respiratory infections in Down syndrome were performed. Previously identified review articles were also assessed. The quality of available evidence was then evaluated and knowledge gaps were identified. Forty-two relevant original articles were identified which addressed at least one key question. Study details including research design, internal validity, external validity, and relevant results are presented. Pneumonia and respiratory infections are more prevalent and more severe in individuals with Down syndrome compared to healthy controls through literature review, yet there are gaps in the literature regarding the etiology of pneumonia, the infectious organism, risk factors for infection, and to guide options for prevention and screening. There is urgent need for additional research studies in Down syndrome, especially in the time of the current COVID-19 pandemic.
AB - Pneumonia and respiratory infections impact infants and children with Down syndrome; pneumonia is a leading cause of mortality in adults with Down syndrome. We aimed to review the literature to evaluate gaps and address key questions. A series of key questions were formulated a priori to inform the search strategy and review process; addressed prevalence, severity, etiology, risk factors, preventive methods, screening, and financial costs, potential benefits or harms of screening. Using the National Library of Medicine database, PubMed, detailed literature searches on pneumonia and respiratory infections in Down syndrome were performed. Previously identified review articles were also assessed. The quality of available evidence was then evaluated and knowledge gaps were identified. Forty-two relevant original articles were identified which addressed at least one key question. Study details including research design, internal validity, external validity, and relevant results are presented. Pneumonia and respiratory infections are more prevalent and more severe in individuals with Down syndrome compared to healthy controls through literature review, yet there are gaps in the literature regarding the etiology of pneumonia, the infectious organism, risk factors for infection, and to guide options for prevention and screening. There is urgent need for additional research studies in Down syndrome, especially in the time of the current COVID-19 pandemic.
KW - Down syndrome
KW - pneumonia
KW - respiratory
KW - trisomy 21
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U2 - 10.1002/ajmg.a.61924
DO - 10.1002/ajmg.a.61924
M3 - Review article
C2 - 33073471
AN - SCOPUS:85092712614
SN - 1552-4825
VL - 185
SP - 286
EP - 299
JO - American Journal of Medical Genetics, Part A
JF - American Journal of Medical Genetics, Part A
IS - 1
ER -