Pneumocystis carinii pneumonitis in children with malignancies

Walter T. Hughes, Robert A. Price, Ho Kyun Kim, Thomas P. Coburn, David Grigsby, Sandor Feldman

Research output: Contribution to journalArticle

Abstract

Pneumocystis carinii pneumonitis occurred in 51 (4.1 per cent) of 1,251 children with malignancies. The annual incidence was proportional to the number of patients at risk and was unrelated to season, age, sex, place of residence, or the environmental factors investigated. The disease was characterized by fever, marked tachypnea, flaring of nasal alae, intercostal retraction, frequently cyanosis, and roentgenographic evidence of bilateral diffuse alveolar disease. The diagnosis was established by the identification of P. carinii in material obtained from percutaneous transthoracic needle aspiration of the lung. Three stages of the pathologic pattern were delineated in correlation with clinical manifestations. Forty-one patients were treated with pentamidine isethionate; 28 (68 per cent) of them recovered from the pulmonary infection. A second episode occurred in four. Adverse effects of the drug are usually reversible.

Original languageEnglish (US)
Pages (from-to)404-415
Number of pages12
JournalJournal of Pediatrics
Volume82
Issue number3
DOIs
StatePublished - 1973
Externally publishedYes

Fingerprint

Pneumocystis carinii
Pneumonia
Pentamidine
Tachypnea
Lung
Cyanosis
Nose
Needles
Neoplasms
Fever
Incidence
Infection
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Hughes, W. T., Price, R. A., Kim, H. K., Coburn, T. P., Grigsby, D., & Feldman, S. (1973). Pneumocystis carinii pneumonitis in children with malignancies. Journal of Pediatrics, 82(3), 404-415. https://doi.org/10.1016/S0022-3476(73)80113-1

Pneumocystis carinii pneumonitis in children with malignancies. / Hughes, Walter T.; Price, Robert A.; Kim, Ho Kyun; Coburn, Thomas P.; Grigsby, David; Feldman, Sandor.

In: Journal of Pediatrics, Vol. 82, No. 3, 1973, p. 404-415.

Research output: Contribution to journalArticle

Hughes, WT, Price, RA, Kim, HK, Coburn, TP, Grigsby, D & Feldman, S 1973, 'Pneumocystis carinii pneumonitis in children with malignancies', Journal of Pediatrics, vol. 82, no. 3, pp. 404-415. https://doi.org/10.1016/S0022-3476(73)80113-1
Hughes WT, Price RA, Kim HK, Coburn TP, Grigsby D, Feldman S. Pneumocystis carinii pneumonitis in children with malignancies. Journal of Pediatrics. 1973;82(3):404-415. https://doi.org/10.1016/S0022-3476(73)80113-1
Hughes, Walter T. ; Price, Robert A. ; Kim, Ho Kyun ; Coburn, Thomas P. ; Grigsby, David ; Feldman, Sandor. / Pneumocystis carinii pneumonitis in children with malignancies. In: Journal of Pediatrics. 1973 ; Vol. 82, No. 3. pp. 404-415.
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