Pneumocystis carinii pneumonitis in children with malignancies

Walter T. Hughes, Robert A. Price, Ho Kyun Kim, Thomas P. Coburn, David Grigsby, Sandor Feldman

Research output: Contribution to journalArticlepeer-review

104 Scopus citations


Pneumocystis carinii pneumonitis occurred in 51 (4.1 per cent) of 1,251 children with malignancies. The annual incidence was proportional to the number of patients at risk and was unrelated to season, age, sex, place of residence, or the environmental factors investigated. The disease was characterized by fever, marked tachypnea, flaring of nasal alae, intercostal retraction, frequently cyanosis, and roentgenographic evidence of bilateral diffuse alveolar disease. The diagnosis was established by the identification of P. carinii in material obtained from percutaneous transthoracic needle aspiration of the lung. Three stages of the pathologic pattern were delineated in correlation with clinical manifestations. Forty-one patients were treated with pentamidine isethionate; 28 (68 per cent) of them recovered from the pulmonary infection. A second episode occurred in four. Adverse effects of the drug are usually reversible.

Original languageEnglish (US)
Pages (from-to)404-415
Number of pages12
JournalThe Journal of pediatrics
Issue number3
StatePublished - Mar 1973

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


Dive into the research topics of 'Pneumocystis carinii pneumonitis in children with malignancies'. Together they form a unique fingerprint.

Cite this