TY - JOUR
T1 - Pneumocystis carinii pneumonitis in children with malignancies
AU - Hughes, Walter T.
AU - Price, Robert A.
AU - Kim, Ho Kyun
AU - Coburn, Thomas P.
AU - Grigsby, David
AU - Feldman, Sandor
N1 - Funding Information:
Supported by General Research Support Grant RR-05584, Cancer Research Center Grant CA-08480, and Special Fellowship Grant CA-52170-01, Clinical Cancer Training Grant CA-0815I, National Cancer Institute, National Institutes of Health, and by American-Lebanese-Syrian Association Charities. Presented in part at the Society for Pediatric Research, Washington, D. C., May 25, 1972.
PY - 1973/3
Y1 - 1973/3
N2 - Pneumocystis carinii pneumonitis occurred in 51 (4.1 per cent) of 1,251 children with malignancies. The annual incidence was proportional to the number of patients at risk and was unrelated to season, age, sex, place of residence, or the environmental factors investigated. The disease was characterized by fever, marked tachypnea, flaring of nasal alae, intercostal retraction, frequently cyanosis, and roentgenographic evidence of bilateral diffuse alveolar disease. The diagnosis was established by the identification of P. carinii in material obtained from percutaneous transthoracic needle aspiration of the lung. Three stages of the pathologic pattern were delineated in correlation with clinical manifestations. Forty-one patients were treated with pentamidine isethionate; 28 (68 per cent) of them recovered from the pulmonary infection. A second episode occurred in four. Adverse effects of the drug are usually reversible.
AB - Pneumocystis carinii pneumonitis occurred in 51 (4.1 per cent) of 1,251 children with malignancies. The annual incidence was proportional to the number of patients at risk and was unrelated to season, age, sex, place of residence, or the environmental factors investigated. The disease was characterized by fever, marked tachypnea, flaring of nasal alae, intercostal retraction, frequently cyanosis, and roentgenographic evidence of bilateral diffuse alveolar disease. The diagnosis was established by the identification of P. carinii in material obtained from percutaneous transthoracic needle aspiration of the lung. Three stages of the pathologic pattern were delineated in correlation with clinical manifestations. Forty-one patients were treated with pentamidine isethionate; 28 (68 per cent) of them recovered from the pulmonary infection. A second episode occurred in four. Adverse effects of the drug are usually reversible.
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U2 - 10.1016/S0022-3476(73)80113-1
DO - 10.1016/S0022-3476(73)80113-1
M3 - Article
C2 - 4572932
AN - SCOPUS:0015594703
VL - 82
SP - 404
EP - 415
JO - Journal of Pediatrics
JF - Journal of Pediatrics
SN - 0022-3476
IS - 3
ER -