Pneumococcal infections in children after transplantation

G. E. Schutze, Jr Mason, E. R. Wald, W. J. Barson, J. S. Bradley, T. Q. Tan, Sik Kim Kwang Sik Kim, L. B. Givner, R. Yogev, S. L. Kaplan

Research output: Contribution to journalArticlepeer-review

Abstract

Bacterial infections in recipients of bone marrow and solid-organ transplants remain a major cause of morbidity and death. The cases of 42 children who had undergone transplantation and developed an infection with Streptococcus pneumoniae were retrospectively reviewed. Thirty-four patients had 1 episode of infection, whereas 7 had 2 episodes and 1 had 3 episodes of infection. Solid-organ recipients were more likely to have recurrent invasive disease (P<.02). A total of 31 (74%) of 42 patients were on immunosuppressive therapy, and 74% had been on antimicrobial therapy within 30 days before diagnosis of S. pneumoniae infection. Only 33% of eligible patients had received a pneumococcal vaccine. Twenty-six percent of isolates recovered were not susceptible to penicillin, and 18% were not susceptible to ceftriaxone. Two patients experienced infection-related deaths; one of these had a penicillin-nonsusceptible isolate. The antimicrobial susceptibilities and outcome of infections with S. pneumoniae in patients who have undergone transplantation are similar to those in the general pediatric population.

Original languageEnglish (US)
Pages (from-to)16-21
Number of pages6
JournalClinical Infectious Diseases
Volume33
Issue number1
DOIs
StatePublished - 2001

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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