TY - JOUR
T1 - Vaccins antipneumococciques conjugués et hospitalisation des enfants atteints de pneumonie
T2 - Analyse d’une série chronologique en Afrique du Sud entre 2006 et 2014
AU - Izu, Alane
AU - Solomon, Fatima
AU - Nzenze, Susan A.
AU - Mudau, Azwifarwi
AU - Zell, Elizabeth
AU - O’Brien, Katherine L.
AU - Whitney, Cynthia G.
AU - Verani, Jennifer
AU - Groome, Michelle
AU - Madhi, Shabir A.
N1 - Funding Information:
Our findings appear to be the first from an analysis – of the temporal as sociation of pneumonia hospitalizations with the introduction of pneumococcal conjugate vaccines into the public im munization programme of any African country – that includes prevaccine data. Our findings add to the increasing body of evidence indicating that routine immunization with pneumococcal conjugate vaccines prevents a range of disease outcomes when used on different schedules and in areas with high-or low-disease burdens. ■ Funding: This study was financed by Gavi, the vaccine alliance, through a contract with the Program for Appropriate Technology in Health.
Publisher Copyright:
© WHO 2017.
PY - 2017/9
Y1 - 2017/9
N2 - Objective To assess the impact of immunization with pneumococcal conjugate vaccines on all-cause pneumonia hospitalizations among children in Soweto, South Africa. Methods We used data collected at the Chris Hani Baragwanath Hospital in Soweto between 2006 and 2014 – i.e. before and after April 2009, when a pneumococcal conjugate vaccine was first included in South Africa’s routine immunization programme. Using a Bayesian generalized seasonal autoregressive moving-average model and the data collected in 2006–2008, we estimated the numbers of children that would have been hospitalized for pneumonia between 2010 and 2014 if no pneumococcal conjugate vaccines had been used. These estimates were then compared with the corresponding numbers of hospitalizations observed. Findings Between 2006 and 2014, 26 778 children younger than five years – including 3388 known to be infected with human immunodeficiency virus (HIV) – were admitted to the study hospital for pneumonia. We estimated that, for the children known to be infected with HIV and for the other children, pneumococcal conjugate vaccines reduced the numbers of hospitalizations for pneumonia in 2014 by 33% (50% credible interval, CrI: 6 to 52) and 39% (50% CrI: 24 to 50), respectively. In the study hospital in 2012–2014, as a result of immunizations with these vaccines, there were an estimated 3100 fewer pneumonia hospitalizations of children younger than five years. Conclusion In our study hospital, following the introduction of pneumococcal conjugate vaccines into the national immunization programme, there were significant reductions in pneumonia hospitalizations among children.
AB - Objective To assess the impact of immunization with pneumococcal conjugate vaccines on all-cause pneumonia hospitalizations among children in Soweto, South Africa. Methods We used data collected at the Chris Hani Baragwanath Hospital in Soweto between 2006 and 2014 – i.e. before and after April 2009, when a pneumococcal conjugate vaccine was first included in South Africa’s routine immunization programme. Using a Bayesian generalized seasonal autoregressive moving-average model and the data collected in 2006–2008, we estimated the numbers of children that would have been hospitalized for pneumonia between 2010 and 2014 if no pneumococcal conjugate vaccines had been used. These estimates were then compared with the corresponding numbers of hospitalizations observed. Findings Between 2006 and 2014, 26 778 children younger than five years – including 3388 known to be infected with human immunodeficiency virus (HIV) – were admitted to the study hospital for pneumonia. We estimated that, for the children known to be infected with HIV and for the other children, pneumococcal conjugate vaccines reduced the numbers of hospitalizations for pneumonia in 2014 by 33% (50% credible interval, CrI: 6 to 52) and 39% (50% CrI: 24 to 50), respectively. In the study hospital in 2012–2014, as a result of immunizations with these vaccines, there were an estimated 3100 fewer pneumonia hospitalizations of children younger than five years. Conclusion In our study hospital, following the introduction of pneumococcal conjugate vaccines into the national immunization programme, there were significant reductions in pneumonia hospitalizations among children.
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U2 - 10.2471/BLT.16.187849
DO - 10.2471/BLT.16.187849
M3 - Article
C2 - 28867842
AN - SCOPUS:85028777999
SN - 0042-9686
VL - 95
SP - 618
EP - 628
JO - Bulletin of the World Health Organization
JF - Bulletin of the World Health Organization
IS - 9
ER -