PMv neuronal firing may be driven by a movement command trajectory within multidimensional gaussian fields

Rahul Agarwal, Nitish V Thakor, Sridevi V. Sarma, Steve G. Massaquoi

Research output: Contribution to journalArticle

Abstract

The premotor cortex (PM) is known to be a site of visuo-somatosensory integration for the production of movement.Wesought to better understand the ventral PM (PMv) by modeling its signal encoding in greater detail. Neuronal firing data was obtained from 110 PMv neurons in two male rhesus macaques executing four reach-grasp-manipulate tasks. We found that in the large majority of neurons (~90%) the firing patterns across the four tasks could be explained by assuming that a high-dimensional position/configuration trajectory-like signal evolving ~ 250msbefore movement was encoded within a multidimensional Gaussian field (MGF). Our findings are consistent with the possibility that PMv neurons process a visually specified reference command for the intended arm/hand position trajectory with respect to a proprioceptively or visually sensed initial configuration. The estimated MGF were (hyper) disc-like, such that each neuron’s firing modulated strongly only with commands that evolved along a single direction within position/configuration space. Thus, many neurons appeared to be tuned to slices of this input signal space that as a collection appeared to well cover the space. The MGF encoding models appear to be consistent with the arm-referent, bell-shaped, visual target tuning curves and target selectivity patterns observed in PMV visual-motor neurons. These findings suggest that PMv may implement a lookup table-like mechanism that helps translate intended movementtrajectory into time-varying patterns of activation inmotorcortexandspinal cord.MGFsprovide an improved nonlinear framework for potentially decoding visually specified, intended multijoint arm/hand trajectories well in advance of movement.

Original languageEnglish (US)
Pages (from-to)9508-9525
Number of pages18
JournalJournal of Neuroscience
Volume35
Issue number25
DOIs
StatePublished - Jun 24 2015

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Neurons
Arm
Motor Cortex
Hand
Motor Neurons
Hand Strength
Macaca mulatta

Keywords

  • Brain machine interface
  • MGF
  • Movement command
  • Position/Configuration
  • Premotor cortex
  • Reach and grasp

ASJC Scopus subject areas

  • Neuroscience(all)
  • Medicine(all)

Cite this

PMv neuronal firing may be driven by a movement command trajectory within multidimensional gaussian fields. / Agarwal, Rahul; Thakor, Nitish V; Sarma, Sridevi V.; Massaquoi, Steve G.

In: Journal of Neuroscience, Vol. 35, No. 25, 24.06.2015, p. 9508-9525.

Research output: Contribution to journalArticle

Agarwal, Rahul ; Thakor, Nitish V ; Sarma, Sridevi V. ; Massaquoi, Steve G. / PMv neuronal firing may be driven by a movement command trajectory within multidimensional gaussian fields. In: Journal of Neuroscience. 2015 ; Vol. 35, No. 25. pp. 9508-9525.
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