Pleural fluid and peripheral blood lymphocyte function in tuberculosis

J. J. Ellner

Research output: Contribution to journalArticlepeer-review

60 Scopus citations


The studies show that skin test and peripheral blood mononuclear cell hyporeactivity to tuberculin in these patients with tuberculous pleurisy is not due to depletion of antigen reactive cells from the circulating compartment. Rather, potentially tuberculin-responsive T cells continue to circulate, but their function is masked by suppressor adherent cells. Monocytes present in increased numbers and with increased inhibitory activity appear to provide the basis for in-vitro suppression of peripheral blood lymphocyte responses to tuberculin antigens noted in some patients with pulmonary tuberculosis. The findings suggest that the compartmentalization relevant in tuberculin-hyporesponsive patients with tuberculous pleurisy may be the relative exclusion of such suppressor cells from the pleural space.

Original languageEnglish (US)
Pages (from-to)932-933
Number of pages2
JournalAnnals of Internal Medicine
Issue number6
StatePublished - 1978
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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