Pleiotropic effect of common variants at ABO glycosyltranferase locus in 9q32 on plasma levels of pancreatic lipase and angiotensin converting enzyme

Takamasa Kayama; Hidetoshi Yamashita; Akira Fukao; Isao Kubota; Takeo Kato; Chifumi Kitanaka; Shinya Sato; Yoshiyuki Ueno; Tsuneo Konta; Yoko Shibata; Tetsu Watanabe; Shuichi Abe; Takuya Miyamoto; Sumito Inoue; Takehiko Miyashita; Kazunobu Ichikawa; Tetsuro Shishido; Takanori Arimoto; Hiroki Takahashi; Satoshi Nishiyama; Ami Ikeda; Makoto Daimon; Toru Kawanami; Manabu Wada; Shigeki Arawaka; Hidetoshi Oizumi; Katsuro Kurokawa; Shingi Susa; Yuichi Katou; Wataru Kameda; Shingo Koyama; Shigeru Karasawa; Chifumi Iseki; Yoshimi Takahashi; Sumio Kawata; Takafumi Saito; Naohiko Makino; Kazuo Okumoto; Hiroaki Haga; Takeshi Sato; Chikako Sato; Hisayoshi Watanabe; Yuko Nishise; Rika Ishii; Akiko Matsuda; Tomohiro Tozawa; Kei Honma; Hiroto Narimatsu; Kyoko Shibata; Akiko Miura; Rina Inoue; Ai Numazawa; Kahori Kudo; Yoko Aita; Noriko Umezawa; Yuko Saito; Yumi Takahashi; Yuka Suzuki; Katsumi Otani; Atsushi Hozawa; Li Shao; Masatsugu Orui; Atsuko Kobayashi; Yuka Kanoya; Takiko Hosoya; Ikuko Suzuki; Mariko Otake; Yuko Morikagi; Akiko Sekimata; Manami Hiraka; Yumi Matsuda; Yoko Takeda; Yoko Matsunami; Tatsuya Horie; Shiho Sato; Mizue Inoue; Kaoru Baba; Gen Tamiya; Masao Ueki; Tomohiro Nakamura; Jamiyansuren Jambaldorj; Satoko Araki; Osamu Nakajima; Kazuei Takahashi; Kazuo Goto; Kimishige Ishizaka

doi:10.1371/journal.pone.0055903

Pleiotropic effect of common variants at ABO glycosyltranferase locus in 9q32 on plasma levels of pancreatic lipase and angiotensin converting enzyme

Takamasa Kayama, Hidetoshi Yamashita, Akira Fukao, Isao Kubota, Takeo Kato, Chifumi Kitanaka, Shinya Sato, Yoshiyuki Ueno, Tsuneo Konta, Yoko Shibata, Tetsu Watanabe, Shuichi Abe, Takuya Miyamoto, Sumito Inoue, Takehiko Miyashita, Kazunobu Ichikawa, Tetsuro Shishido, Takanori Arimoto, Hiroki Takahashi, Satoshi NishiyamaAmi Ikeda, Makoto Daimon, Toru Kawanami, Manabu Wada, Shigeki Arawaka, Hidetoshi Oizumi, Katsuro Kurokawa, Shingi Susa, Yuichi Katou, Wataru Kameda, Shingo Koyama, Shigeru Karasawa, Chifumi Iseki, Yoshimi Takahashi, Sumio Kawata, Takafumi Saito, Naohiko Makino, Kazuo Okumoto, Hiroaki Haga, Takeshi Sato, Chikako Sato, Hisayoshi Watanabe, Yuko Nishise, Rika Ishii, Akiko Matsuda, Tomohiro Tozawa, Kei Honma, Hiroto Narimatsu, Kyoko Shibata, Akiko Miura, Rina Inoue, Ai Numazawa, Kahori Kudo, Yoko Aita, Noriko Umezawa, Yuko Saito, Yumi Takahashi, Yuka Suzuki, Katsumi Otani, Atsushi Hozawa, Li Shao, Masatsugu Orui, Atsuko Kobayashi, Yuka Kanoya, Takiko Hosoya, Ikuko Suzuki, Mariko Otake, Yuko Morikagi, Akiko Sekimata, Manami Hiraka, Yumi Matsuda, Yoko Takeda, Yoko Matsunami, Tatsuya Horie, Shiho Sato, Mizue Inoue, Kaoru Baba, Gen Tamiya, Masao Ueki, Tomohiro Nakamura, Jamiyansuren Jambaldorj, Satoko Araki, Osamu Nakajima, Kazuei Takahashi, Kazuo Goto, Kimishige Ishizaka

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

For forty-three clinical test values presumably associated to common complex human diseases, we carried out a genomewide association study using 600K SNPs in a general Japanese population of 1,639 individuals (1,252 after quality control procedures) drawn from a regional cohort, followed by a replication study for statistically significant SNPs (p = 1.95×10^-9- 8.34×10^-39) using an independent population of 1,671 from another cohort. In this single two-stage study, we newly found strong and robust associations of common variants at the ABO histo-blood glycosyltransferase locus in 9q32 with the plasma levels of pancreatic lipase (P-LIP), in addition to successful confirmation of the known ABO association of angiotensin converting enzyme (ACE) independent of the ACE1 gene in 17q23.2 with the ACE level. Our results are compatible with the previously reported association between the ABO gene and pancreatic cancer, and show that the effect of these common variants at the ABO locus on the P-LIP and ACE levels is largely opposing and pleiotropic.

Original language	English (US)
Article number	e55903
Journal	PloS one
Volume	9
Issue number	2
DOIs	https://doi.org/10.1371/journal.pone.0055903
State	Published - Feb 28 2014
Externally published	Yes

ASJC Scopus subject areas

General

Access to Document

10.1371/journal.pone.0055903

Cite this

Kayama, T., Yamashita, H., Fukao, A., Kubota, I., Kato, T., Kitanaka, C., Sato, S., Ueno, Y., Konta, T., Shibata, Y., Watanabe, T., Abe, S., Miyamoto, T., Inoue, S., Miyashita, T., Ichikawa, K., Shishido, T., Arimoto, T., Takahashi, H., ... Ishizaka, K. (2014). Pleiotropic effect of common variants at ABO glycosyltranferase locus in 9q32 on plasma levels of pancreatic lipase and angiotensin converting enzyme. PloS one, 9(2), Article e55903. https://doi.org/10.1371/journal.pone.0055903

Kayama, T, Yamashita, H, Fukao, A, Kubota, I, Kato, T, Kitanaka, C, Sato, S, Ueno, Y, Konta, T, Shibata, Y, Watanabe, T, Abe, S, Miyamoto, T, Inoue, S, Miyashita, T, Ichikawa, K, Shishido, T, Arimoto, T, Takahashi, H, Nishiyama, S, Ikeda, A, Daimon, M, Kawanami, T, Wada, M, Arawaka, S, Oizumi, H, Kurokawa, K, Susa, S, Katou, Y, Kameda, W, Koyama, S, Karasawa, S, Iseki, C, Takahashi, Y, Kawata, S, Saito, T, Makino, N, Okumoto, K, Haga, H, Sato, T, Sato, C, Watanabe, H, Nishise, Y, Ishii, R, Matsuda, A, Tozawa, T, Honma, K, Narimatsu, H, Shibata, K, Miura, A, Inoue, R, Numazawa, A, Kudo, K, Aita, Y, Umezawa, N, Saito, Y, Takahashi, Y, Suzuki, Y, Otani, K, Hozawa, A, Shao, L, Orui, M, Kobayashi, A, Kanoya, Y, Hosoya, T, Suzuki, I, Otake, M, Morikagi, Y, Sekimata, A, Hiraka, M, Matsuda, Y, Takeda, Y, Matsunami, Y, Horie, T, Sato, S, Inoue, M, Baba, K, Tamiya, G, Ueki, M, Nakamura, T, Jambaldorj, J, Araki, S, Nakajima, O, Takahashi, K, Goto, K & Ishizaka, K 2014, 'Pleiotropic effect of common variants at ABO glycosyltranferase locus in 9q32 on plasma levels of pancreatic lipase and angiotensin converting enzyme', PloS one, vol. 9, no. 2, e55903. https://doi.org/10.1371/journal.pone.0055903

@article{d41f9bb1221b403a9860e783c862f5f2,

title = "Pleiotropic effect of common variants at ABO glycosyltranferase locus in 9q32 on plasma levels of pancreatic lipase and angiotensin converting enzyme",

abstract = "For forty-three clinical test values presumably associated to common complex human diseases, we carried out a genomewide association study using 600K SNPs in a general Japanese population of 1,639 individuals (1,252 after quality control procedures) drawn from a regional cohort, followed by a replication study for statistically significant SNPs (p = 1.95×10-9- 8.34×10-39) using an independent population of 1,671 from another cohort. In this single two-stage study, we newly found strong and robust associations of common variants at the ABO histo-blood glycosyltransferase locus in 9q32 with the plasma levels of pancreatic lipase (P-LIP), in addition to successful confirmation of the known ABO association of angiotensin converting enzyme (ACE) independent of the ACE1 gene in 17q23.2 with the ACE level. Our results are compatible with the previously reported association between the ABO gene and pancreatic cancer, and show that the effect of these common variants at the ABO locus on the P-LIP and ACE levels is largely opposing and pleiotropic.",

author = "Takamasa Kayama and Hidetoshi Yamashita and Akira Fukao and Isao Kubota and Takeo Kato and Chifumi Kitanaka and Shinya Sato and Yoshiyuki Ueno and Tsuneo Konta and Yoko Shibata and Tetsu Watanabe and Shuichi Abe and Takuya Miyamoto and Sumito Inoue and Takehiko Miyashita and Kazunobu Ichikawa and Tetsuro Shishido and Takanori Arimoto and Hiroki Takahashi and Satoshi Nishiyama and Ami Ikeda and Makoto Daimon and Toru Kawanami and Manabu Wada and Shigeki Arawaka and Hidetoshi Oizumi and Katsuro Kurokawa and Shingi Susa and Yuichi Katou and Wataru Kameda and Shingo Koyama and Shigeru Karasawa and Chifumi Iseki and Yoshimi Takahashi and Sumio Kawata and Takafumi Saito and Naohiko Makino and Kazuo Okumoto and Hiroaki Haga and Takeshi Sato and Chikako Sato and Hisayoshi Watanabe and Yuko Nishise and Rika Ishii and Akiko Matsuda and Tomohiro Tozawa and Kei Honma and Hiroto Narimatsu and Kyoko Shibata and Akiko Miura and Rina Inoue and Ai Numazawa and Kahori Kudo and Yoko Aita and Noriko Umezawa and Yuko Saito and Yumi Takahashi and Yuka Suzuki and Katsumi Otani and Atsushi Hozawa and Li Shao and Masatsugu Orui and Atsuko Kobayashi and Yuka Kanoya and Takiko Hosoya and Ikuko Suzuki and Mariko Otake and Yuko Morikagi and Akiko Sekimata and Manami Hiraka and Yumi Matsuda and Yoko Takeda and Yoko Matsunami and Tatsuya Horie and Shiho Sato and Mizue Inoue and Kaoru Baba and Gen Tamiya and Masao Ueki and Tomohiro Nakamura and Jamiyansuren Jambaldorj and Satoko Araki and Osamu Nakajima and Kazuei Takahashi and Kazuo Goto and Kimishige Ishizaka",

year = "2014",

month = feb,

day = "28",

doi = "10.1371/journal.pone.0055903",

language = "English (US)",

volume = "9",

journal = "PloS one",

issn = "1932-6203",

publisher = "Public Library of Science",

number = "2",

}

TY - JOUR

T1 - Pleiotropic effect of common variants at ABO glycosyltranferase locus in 9q32 on plasma levels of pancreatic lipase and angiotensin converting enzyme

AU - Kayama, Takamasa

AU - Yamashita, Hidetoshi

AU - Fukao, Akira

AU - Kubota, Isao

AU - Kato, Takeo

AU - Kitanaka, Chifumi

AU - Sato, Shinya

AU - Ueno, Yoshiyuki

AU - Konta, Tsuneo

AU - Shibata, Yoko

AU - Watanabe, Tetsu

AU - Abe, Shuichi

AU - Miyamoto, Takuya

AU - Inoue, Sumito

AU - Miyashita, Takehiko

AU - Ichikawa, Kazunobu

AU - Shishido, Tetsuro

AU - Arimoto, Takanori

AU - Takahashi, Hiroki

AU - Nishiyama, Satoshi

AU - Ikeda, Ami

AU - Daimon, Makoto

AU - Kawanami, Toru

AU - Wada, Manabu

AU - Arawaka, Shigeki

AU - Oizumi, Hidetoshi

AU - Kurokawa, Katsuro

AU - Susa, Shingi

AU - Katou, Yuichi

AU - Kameda, Wataru

AU - Koyama, Shingo

AU - Karasawa, Shigeru

AU - Iseki, Chifumi

AU - Takahashi, Yoshimi

AU - Kawata, Sumio

AU - Saito, Takafumi

AU - Makino, Naohiko

AU - Okumoto, Kazuo

AU - Haga, Hiroaki

AU - Sato, Takeshi

AU - Sato, Chikako

AU - Watanabe, Hisayoshi

AU - Nishise, Yuko

AU - Ishii, Rika

AU - Matsuda, Akiko

AU - Tozawa, Tomohiro

AU - Honma, Kei

AU - Narimatsu, Hiroto

AU - Shibata, Kyoko

AU - Miura, Akiko

AU - Inoue, Rina

AU - Numazawa, Ai

AU - Kudo, Kahori

AU - Aita, Yoko

AU - Umezawa, Noriko

AU - Saito, Yuko

AU - Takahashi, Yumi

AU - Suzuki, Yuka

AU - Otani, Katsumi

AU - Hozawa, Atsushi

AU - Shao, Li

AU - Orui, Masatsugu

AU - Kobayashi, Atsuko

AU - Kanoya, Yuka

AU - Hosoya, Takiko

AU - Suzuki, Ikuko

AU - Otake, Mariko

AU - Morikagi, Yuko

AU - Sekimata, Akiko

AU - Hiraka, Manami

AU - Matsuda, Yumi

AU - Takeda, Yoko

AU - Matsunami, Yoko

AU - Horie, Tatsuya

AU - Sato, Shiho

AU - Inoue, Mizue

AU - Baba, Kaoru

AU - Tamiya, Gen

AU - Ueki, Masao

AU - Nakamura, Tomohiro

AU - Jambaldorj, Jamiyansuren

AU - Araki, Satoko

AU - Nakajima, Osamu

AU - Takahashi, Kazuei

AU - Goto, Kazuo

AU - Ishizaka, Kimishige

PY - 2014/2/28

Y1 - 2014/2/28

N2 - For forty-three clinical test values presumably associated to common complex human diseases, we carried out a genomewide association study using 600K SNPs in a general Japanese population of 1,639 individuals (1,252 after quality control procedures) drawn from a regional cohort, followed by a replication study for statistically significant SNPs (p = 1.95×10-9- 8.34×10-39) using an independent population of 1,671 from another cohort. In this single two-stage study, we newly found strong and robust associations of common variants at the ABO histo-blood glycosyltransferase locus in 9q32 with the plasma levels of pancreatic lipase (P-LIP), in addition to successful confirmation of the known ABO association of angiotensin converting enzyme (ACE) independent of the ACE1 gene in 17q23.2 with the ACE level. Our results are compatible with the previously reported association between the ABO gene and pancreatic cancer, and show that the effect of these common variants at the ABO locus on the P-LIP and ACE levels is largely opposing and pleiotropic.

AB - For forty-three clinical test values presumably associated to common complex human diseases, we carried out a genomewide association study using 600K SNPs in a general Japanese population of 1,639 individuals (1,252 after quality control procedures) drawn from a regional cohort, followed by a replication study for statistically significant SNPs (p = 1.95×10-9- 8.34×10-39) using an independent population of 1,671 from another cohort. In this single two-stage study, we newly found strong and robust associations of common variants at the ABO histo-blood glycosyltransferase locus in 9q32 with the plasma levels of pancreatic lipase (P-LIP), in addition to successful confirmation of the known ABO association of angiotensin converting enzyme (ACE) independent of the ACE1 gene in 17q23.2 with the ACE level. Our results are compatible with the previously reported association between the ABO gene and pancreatic cancer, and show that the effect of these common variants at the ABO locus on the P-LIP and ACE levels is largely opposing and pleiotropic.

UR - http://www.scopus.com/inward/record.url?scp=84896498338&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84896498338&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0055903

DO - 10.1371/journal.pone.0055903

M3 - Article

C2 - 24586218

AN - SCOPUS:84896498338

SN - 1932-6203

VL - 9

JO - PloS one

JF - PloS one

IS - 2

M1 - e55903

ER -

Pleiotropic effect of common variants at ABO glycosyltranferase locus in 9q32 on plasma levels of pancreatic lipase and angiotensin converting enzyme

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this