Platelets present antigen in the context of MHC class I

Lesley M. Chapman, Angela A. Aggrey, David J. Field, Kalyan Srivastava, Sara Ture, Katsuyuki Yui, David J. Topham, William M. Baldwin, Craig N. Morrell

Research output: Contribution to journalArticlepeer-review

Abstract

Platelets are most recognized for their vital role as the cellular mediator of thrombosis, but platelets also have important immune functions. Platelets initiate and sustain vascular inflammation in many disease conditions, including arthritis, atherosclerosis, transplant rejection, and severe malaria. We now demonstrate that platelets express T cell costimulatory molecules, process and present Ag in MHC class I, and directly activate naive T cells in a platelet MHC class I-dependent manner. Using an experimental cerebral malaria mouse model, we also demonstrate that platelets present pathogen-derived Ag to promote T cell responses in vivo, and that platelets can be used in a cell-based vaccine model to induce protective immune responses. Our study demonstrates a novel Ag presentation role for platelets.

Original languageEnglish (US)
Pages (from-to)916-923
Number of pages8
JournalJournal of Immunology
Volume189
Issue number2
DOIs
StatePublished - Jul 15 2012
Externally publishedYes

ASJC Scopus subject areas

  • Immunology

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