Platelet Tritiated Imipramine Binding and Serotonin Uptake in Depressed Patients and Controls: Relationship to Plasma Cortisol Levels Before and After Dexamethasone Administration

Alec Roy, Don Everett, David Pickar, Steven M. Paul

Research output: Contribution to journalArticlepeer-review

Abstract

We measured platelet tritiated imipramine binding and serotonin uptake in 51 depressed patients and 43 normal controls. Although there were no significant differences in platelet 3H-imipramine binding or serotonin uptake when the total group of depressed patients was compared with controls, depressed women (n = 32) had a significantly lower maximal density of 3H-imipramine binding sites (βmax) than control women (n = 25). Moreover, among the total group of depressed patients, there were significant negative correlations between the βmaxvalues and plasma cortisol levels at 4 PM (n = 41) and 11 PM (n = 41) following dexamethasone administration. These negative correlations between βmaxand cortisol levels were strongest among melancholic patients both at 4 PM before dexamethasone administration (n =14) and at 11 PM after dexamethasone administration (n =15). These data suggest that the reported decrease in βmaxfound among depressed patients may be related to and is perhaps secondary to the hypercortisolemia of depression.

Original languageEnglish (US)
Pages (from-to)320-327
Number of pages8
JournalArchives of General Psychiatry
Volume44
Issue number4
DOIs
StatePublished - 1987
Externally publishedYes

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Psychiatry and Mental health

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