Platelet-Rich Plasma as a Treatment for Androgenetic Alopecia

Aditya K. Gupta, John Cole, David P. Deutsch, Peter A. Everts, Robert P. Niedbalski, Ratchathorn Panchaprateep, Fabio Rinaldi, Paul T. Rose, Rodney Sinclair, James E. Vogel, Ryan J. Welter, Michael D. Zufelt, Carlos J. Puig

Research output: Contribution to journalReview articlepeer-review

Abstract

BACKGROUNDPlatelet-rich plasma (PRP) treatment may encourage hair growth by promoting cellular maturation, differentiation, and proliferation.OBJECTIVEThe objective of this study was to evaluate the effectiveness of PRP as a treatment for androgenetic alopecia (AGA).MATERIALS AND METHODSA literature search combined with meta-analysis was used to calculate the overall standardized mean difference (SMD) in hair density in patients treated with PRP injections in comparison with baseline and placebo treatment. Chi squared analysis and Fisher exact test were used to investigate variation in protocols.RESULTSThe overall SMD in hair density was 0.58 (95% confidence interval [CI]: 0.35-0.80) and 0.51 (95% CI: 0.23-0.80, p <.0004) in favor of PRP treatment when compared with baseline and placebo treatment, respectively.CONCLUSIONPlatelet-rich plasma is beneficial in the treatment of AGA. It is recommended that 3 monthly sessions of PRP (once monthly ×3 treatments) be used followed by a 3-to 6-month maintenance period.

Original languageEnglish (US)
Pages (from-to)1262-1273
Number of pages12
JournalDermatologic Surgery
Volume45
Issue number10
DOIs
StatePublished - Oct 1 2019

ASJC Scopus subject areas

  • Surgery
  • Dermatology

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