Platelet peripheral-type benzodiazepine in pregnancy and lactation

Abraham Weizman; Efrat Dagan; Boris Kaplan; Leon Karp; Suzanna Malmud; Irit Gil-Ad; Svetlana Leschiner; Solomon H. Snyder; Moshe Gavish

doi:10.1016/S0893-133X(98)00122-5

Platelet peripheral-type benzodiazepine in pregnancy and lactation

Abraham Weizman, Efrat Dagan, Boris Kaplan, Leon Karp, Suzanna Malmud, Irit Gil-Ad, Svetlana Leschiner, Solomon H. Snyder, Moshe Gavish

School of Medicine

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The aim of the present study was to investigate the impact of hormonal changes during pregnancy and lactation on the expression of peripheral-type benzodiazepine receptors in platelet membranes. Platelet peripheral benzodiazepine receptor binding characteristics, Hamilton anxiety and depression rating Scores, and progesterone and prolactin (PRL) levels were evaluated during pregnancy and lactation in 17 pregnant women [first (n = 9) and third (n = 8) trimesters], 10 lactating women, and 8 nonpregnant women. A significant decrease (38-41%) in peripheral benzodiazepine receptor density was observed in women during the third trimester of pregnancy when compared to nonpregnant controls and women in their first trimester of pregnancy. The decrease is peripheral benzodiazepine receptors was parallel to the peak in progesterone and PRL secretion. The reduction in peripheral benzodiazepine receptor expression is hormone-dependent and may play a regulatory role geared to prevent pregnancy-related overactivity of the hypothalamic-pituitary-ovarian, hypothalamic-pituitary-adrenal, and hypothalamic-PRL axes. Copyright (C) 1999 American College of Neuropsychopharmacology.

Original language	English (US)
Pages (from-to)	513-518
Number of pages	6
Journal	Neuropsychopharmacology
Volume	21
Issue number	4
DOIs	https://doi.org/10.1016/S0893-133X(98)00122-5
State	Published - Oct 1999

Keywords

Anxiety
Benzodiazepine receptor
Depression
Progesterone
Prolactin

ASJC Scopus subject areas

Pharmacology
Psychiatry and Mental health

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10.1016/S0893-133X(98)00122-5

Cite this

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title = "Platelet peripheral-type benzodiazepine in pregnancy and lactation",

abstract = "The aim of the present study was to investigate the impact of hormonal changes during pregnancy and lactation on the expression of peripheral-type benzodiazepine receptors in platelet membranes. Platelet peripheral benzodiazepine receptor binding characteristics, Hamilton anxiety and depression rating Scores, and progesterone and prolactin (PRL) levels were evaluated during pregnancy and lactation in 17 pregnant women [first (n = 9) and third (n = 8) trimesters], 10 lactating women, and 8 nonpregnant women. A significant decrease (38-41%) in peripheral benzodiazepine receptor density was observed in women during the third trimester of pregnancy when compared to nonpregnant controls and women in their first trimester of pregnancy. The decrease is peripheral benzodiazepine receptors was parallel to the peak in progesterone and PRL secretion. The reduction in peripheral benzodiazepine receptor expression is hormone-dependent and may play a regulatory role geared to prevent pregnancy-related overactivity of the hypothalamic-pituitary-ovarian, hypothalamic-pituitary-adrenal, and hypothalamic-PRL axes. Copyright (C) 1999 American College of Neuropsychopharmacology.",

keywords = "Anxiety, Benzodiazepine receptor, Depression, Progesterone, Prolactin",

author = "Abraham Weizman and Efrat Dagan and Boris Kaplan and Leon Karp and Suzanna Malmud and Irit Gil-Ad and Svetlana Leschiner and Snyder, {Solomon H.} and Moshe Gavish",

note = "Funding Information: The authors thank Ruth Singer for editorial assistance. This work was supported by Grant 91-00146 from the U.S.–Israel Binational Science Foundation and by Grant 181-378 from the Fund for Promotion of Research at the Technion.",

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AU - Weizman, Abraham

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AU - Kaplan, Boris

AU - Karp, Leon

AU - Malmud, Suzanna

AU - Gil-Ad, Irit

AU - Leschiner, Svetlana

AU - Snyder, Solomon H.

AU - Gavish, Moshe

N1 - Funding Information: The authors thank Ruth Singer for editorial assistance. This work was supported by Grant 91-00146 from the U.S.–Israel Binational Science Foundation and by Grant 181-378 from the Fund for Promotion of Research at the Technion.

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N2 - The aim of the present study was to investigate the impact of hormonal changes during pregnancy and lactation on the expression of peripheral-type benzodiazepine receptors in platelet membranes. Platelet peripheral benzodiazepine receptor binding characteristics, Hamilton anxiety and depression rating Scores, and progesterone and prolactin (PRL) levels were evaluated during pregnancy and lactation in 17 pregnant women [first (n = 9) and third (n = 8) trimesters], 10 lactating women, and 8 nonpregnant women. A significant decrease (38-41%) in peripheral benzodiazepine receptor density was observed in women during the third trimester of pregnancy when compared to nonpregnant controls and women in their first trimester of pregnancy. The decrease is peripheral benzodiazepine receptors was parallel to the peak in progesterone and PRL secretion. The reduction in peripheral benzodiazepine receptor expression is hormone-dependent and may play a regulatory role geared to prevent pregnancy-related overactivity of the hypothalamic-pituitary-ovarian, hypothalamic-pituitary-adrenal, and hypothalamic-PRL axes. Copyright (C) 1999 American College of Neuropsychopharmacology.

AB - The aim of the present study was to investigate the impact of hormonal changes during pregnancy and lactation on the expression of peripheral-type benzodiazepine receptors in platelet membranes. Platelet peripheral benzodiazepine receptor binding characteristics, Hamilton anxiety and depression rating Scores, and progesterone and prolactin (PRL) levels were evaluated during pregnancy and lactation in 17 pregnant women [first (n = 9) and third (n = 8) trimesters], 10 lactating women, and 8 nonpregnant women. A significant decrease (38-41%) in peripheral benzodiazepine receptor density was observed in women during the third trimester of pregnancy when compared to nonpregnant controls and women in their first trimester of pregnancy. The decrease is peripheral benzodiazepine receptors was parallel to the peak in progesterone and PRL secretion. The reduction in peripheral benzodiazepine receptor expression is hormone-dependent and may play a regulatory role geared to prevent pregnancy-related overactivity of the hypothalamic-pituitary-ovarian, hypothalamic-pituitary-adrenal, and hypothalamic-PRL axes. Copyright (C) 1999 American College of Neuropsychopharmacology.

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KW - Depression

KW - Progesterone

KW - Prolactin

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Platelet peripheral-type benzodiazepine in pregnancy and lactation

Abstract

Keywords

ASJC Scopus subject areas

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