Platelet imipramine binding and serotonin uptake in obsessive‐compulsive patients

B. Vitiello, H. Shimon, D. Behar, D. Stoff, W. H. Bridger, E. Friedman

Research output: Contribution to journalArticlepeer-review


Platelet imipramine binding was measured in 16 drug‐free nondepressed patients (aged 20‐61 years, mean ± SD 35 ± 8) suffering from obsessive‐compulsive disorder (OCD) and in 16 sex‐, race‐ and age‐matched healthy controls. Imipramine binding capacity and affinity were not different in the 2 groups. Platelet serotonin (5‐HT) uptake capacity, Vmax, was also measured in 15 of these patients and their matched controls. Vmax was significantly higher in the patients (309 ± 149 pmol/109 cells/min) than in the controls (181 ± 110). An increase in platelet 5‐HT uptake supports the involvement of 5‐HT in OCD and may suggest that a hyperactive serotonergic system is present in this disorder.

Original languageEnglish (US)
Pages (from-to)29-32
Number of pages4
JournalActa Psychiatrica Scandinavica
Issue number1
StatePublished - Jul 1991
Externally publishedYes


  • Key words
  • obsessive‐compulsive disorder
  • platelet
  • serotonin
  • uptake

ASJC Scopus subject areas

  • Psychiatry and Mental health


Dive into the research topics of 'Platelet imipramine binding and serotonin uptake in obsessive‐compulsive patients'. Together they form a unique fingerprint.

Cite this