Abstract
Platelet imipramine binding was measured in 16 drug‐free nondepressed patients (aged 20‐61 years, mean ± SD 35 ± 8) suffering from obsessive‐compulsive disorder (OCD) and in 16 sex‐, race‐ and age‐matched healthy controls. Imipramine binding capacity and affinity were not different in the 2 groups. Platelet serotonin (5‐HT) uptake capacity, Vmax, was also measured in 15 of these patients and their matched controls. Vmax was significantly higher in the patients (309 ± 149 pmol/109 cells/min) than in the controls (181 ± 110). An increase in platelet 5‐HT uptake supports the involvement of 5‐HT in OCD and may suggest that a hyperactive serotonergic system is present in this disorder.
Original language | English (US) |
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Pages (from-to) | 29-32 |
Number of pages | 4 |
Journal | Acta Psychiatrica Scandinavica |
Volume | 84 |
Issue number | 1 |
DOIs | |
State | Published - Jul 1991 |
Externally published | Yes |
Keywords
- Key words
- obsessive‐compulsive disorder
- platelet
- serotonin
- uptake
ASJC Scopus subject areas
- Psychiatry and Mental health