TY - JOUR
T1 - Platelet glycoprotein receptor IIIa polymorphism P1A2 and ischemic stroke risk
T2 - The stroke prevention in young women study
AU - Wagner, Kathryn R.
AU - Giles, Wayne H.
AU - Johnson, Constance J.
AU - Ou, Chin Yih
AU - Bray, Paul F.
AU - Goldschmidt-Clermont, Pascal J.
AU - Croft, Janet B.
AU - Brown, Vicki K.
AU - Stern, Barney J.
AU - Feeser, Barbara R.
AU - Buchholz, David W.
AU - Earley, Christopher J.
AU - Macko, Richard F.
AU - McCarter, Robert J.
AU - Sloan, Michael A.
AU - Stolley, Paul D.
AU - Wityk, Robert J.
AU - Wozniak, Marcella A.
AU - Price, Thomas R.
AU - Kittner, Steven J.
PY - 1998/3
Y1 - 1998/3
N2 - Background and Purpose - Platelet glycoprotein IIb/IIIa (GpIIIb-IIIa), a membrane receptor for fibrinogen and von Willebrand factor, has been implicated in the pathogenesis of acute coronary syndromes but has not been previously investigated in relation to stroke in young adults. Methods - We used a population-based case-control design to examine the association of the GpIIIa polymorphism P1A2 with stroke in young women. Subjects were 65 cerebral infarction cases (18 patients with and 47 without an identified probable etiology) 15 to 44 years of age from the Baltimore-Washington region and 122 controls frequency matched by age from the same geographic area. A face-to-face interview for vascular disease risk factors and a blood sample for the P1A2 allele and serum cholesterol were obtained from each participant. Logistic regression was used to estimate the odds ratio for one or more P1A2 alleles after adjustment for other risk factors. Results - Among cases and controls, the prevalence rates of one or more P1A2 alleles were 21% and 22% among blacks and 36% and 28% among whites, respectively. This genotype was significantly associated with hypertension only in black control subjects but otherwise not with any of the established vascular risk factors. The adjusted odds ratio for cerebral infarction of one or more P1A2 alleles was 1.1 (confidence interval [CI], 0.6 to 2.3) overall, 0.5 (CI, 0.1 to 7.1) among blacks, and 1.4 (CI, 0.5 to 3.7) among whites. For the cases with an identified probable etiology, the corresponding odds ratios were 3.0 (CI, 0.9 to 10.4) overall, 0.7 (CI, 0.1 to 7.1) among blacks, and 12.8 (CI, 1.2 to 135.0) among whites. Conclusions - No association was found between the P1A2 polymorphism of GpIIIa and young women with stroke. However, subgroup analyses showed that the P1A2 polymorphism of GpIIIa appeared to be associated with stroke risk among white women, particularly those with a clinically identified probable etiology for their stroke. Further work with an emphasis on stroke subtypes and with multiracial populations is warranted.
AB - Background and Purpose - Platelet glycoprotein IIb/IIIa (GpIIIb-IIIa), a membrane receptor for fibrinogen and von Willebrand factor, has been implicated in the pathogenesis of acute coronary syndromes but has not been previously investigated in relation to stroke in young adults. Methods - We used a population-based case-control design to examine the association of the GpIIIa polymorphism P1A2 with stroke in young women. Subjects were 65 cerebral infarction cases (18 patients with and 47 without an identified probable etiology) 15 to 44 years of age from the Baltimore-Washington region and 122 controls frequency matched by age from the same geographic area. A face-to-face interview for vascular disease risk factors and a blood sample for the P1A2 allele and serum cholesterol were obtained from each participant. Logistic regression was used to estimate the odds ratio for one or more P1A2 alleles after adjustment for other risk factors. Results - Among cases and controls, the prevalence rates of one or more P1A2 alleles were 21% and 22% among blacks and 36% and 28% among whites, respectively. This genotype was significantly associated with hypertension only in black control subjects but otherwise not with any of the established vascular risk factors. The adjusted odds ratio for cerebral infarction of one or more P1A2 alleles was 1.1 (confidence interval [CI], 0.6 to 2.3) overall, 0.5 (CI, 0.1 to 7.1) among blacks, and 1.4 (CI, 0.5 to 3.7) among whites. For the cases with an identified probable etiology, the corresponding odds ratios were 3.0 (CI, 0.9 to 10.4) overall, 0.7 (CI, 0.1 to 7.1) among blacks, and 12.8 (CI, 1.2 to 135.0) among whites. Conclusions - No association was found between the P1A2 polymorphism of GpIIIa and young women with stroke. However, subgroup analyses showed that the P1A2 polymorphism of GpIIIa appeared to be associated with stroke risk among white women, particularly those with a clinically identified probable etiology for their stroke. Further work with an emphasis on stroke subtypes and with multiracial populations is warranted.
KW - Crebrovascular disorders
KW - Platelets
KW - Polymorphism (genetics)
KW - Young adults women
UR - http://www.scopus.com/inward/record.url?scp=20244380013&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=20244380013&partnerID=8YFLogxK
U2 - 10.1161/01.STR.29.3.581
DO - 10.1161/01.STR.29.3.581
M3 - Article
C2 - 9506596
AN - SCOPUS:20244380013
SN - 0039-2499
VL - 29
SP - 581
EP - 585
JO - Stroke
JF - Stroke
IS - 3
ER -