Platelet Function Monitoring in Patients With Coronary Artery Disease

Paul A. Gurbel, Richard C. Becker, Kenneth G. Mann, Steven R. Steinhubl, Alan D. Michelson

Research output: Contribution to journalReview article

Abstract

Studies focused on patient responsiveness to antiplatelet therapies, particularly aspirin and clopidogrel, have increased in recent years. However, the relations of in vivo platelet function and adverse clinical events to results of ex vivo platelet function tests remain largely unknown. This article describes current methods of measuring platelet function in various clinical and research situations and their advantages and disadvantages, reviews evidence for antiplatelet response variability and resistance, discusses the potential pitfalls of monitoring platelet function, and demonstrates emerging data supporting the positive clinical and treatment implications of platelet function testing.

Original languageEnglish (US)
Pages (from-to)1822-1834
Number of pages13
JournalJournal of the American College of Cardiology
Volume50
Issue number19
DOIs
StatePublished - Nov 6 2007

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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  • Cite this

    Gurbel, P. A., Becker, R. C., Mann, K. G., Steinhubl, S. R., & Michelson, A. D. (2007). Platelet Function Monitoring in Patients With Coronary Artery Disease. Journal of the American College of Cardiology, 50(19), 1822-1834. https://doi.org/10.1016/j.jacc.2007.07.051