Platelet function in patients with diabetes mellitus

From a theoretical to a practical perspective

Nicholaos Kakouros, Jeffrey J. Rade, Antonios Kourliouros, Jon R Resar

Research output: Contribution to journalArticle

Abstract

Patients with diabetes mellitus have an increased prevalence of vascular disease. Pathologic thrombosis associated with atherosclerotic plaque rupture is a major cause of morbidity and mortality. Platelets are intimately involved in the initiation and propagation of thrombosis. Evidence suggests that platelets from patients with type 2 diabetes have increased reactivity and baseline activation compared to healthy controls. We review the pathophysiology of platelet hyperreactivity in DM patients and its implications in clinical practice, with particular focus on acute coronary syndromes, percutaneous coronary intervention, and novel antiplatelet agents.

Original languageEnglish (US)
Article number742719
JournalInternational Journal of Endocrinology
Volume2011
DOIs
StatePublished - 2011

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Diabetes Mellitus
Blood Platelets
Thrombosis
Platelet Aggregation Inhibitors
Atherosclerotic Plaques
Percutaneous Coronary Intervention
Acute Coronary Syndrome
Vascular Diseases
Type 2 Diabetes Mellitus
Rupture
Morbidity
Mortality

ASJC Scopus subject areas

  • Endocrine and Autonomic Systems
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Platelet function in patients with diabetes mellitus : From a theoretical to a practical perspective. / Kakouros, Nicholaos; Rade, Jeffrey J.; Kourliouros, Antonios; Resar, Jon R.

In: International Journal of Endocrinology, Vol. 2011, 742719, 2011.

Research output: Contribution to journalArticle

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