Platelet function in patients with diabetes mellitus: From a theoretical to a practical perspective

Nicholaos Kakouros, Jeffrey J. Rade, Antonios Kourliouros, Jon R. Resar

Research output: Contribution to journalReview article


Patients with diabetes mellitus have an increased prevalence of vascular disease. Pathologic thrombosis associated with atherosclerotic plaque rupture is a major cause of morbidity and mortality. Platelets are intimately involved in the initiation and propagation of thrombosis. Evidence suggests that platelets from patients with type 2 diabetes have increased reactivity and baseline activation compared to healthy controls. We review the pathophysiology of platelet hyperreactivity in DM patients and its implications in clinical practice, with particular focus on acute coronary syndromes, percutaneous coronary intervention, and novel antiplatelet agents.

Original languageEnglish (US)
Article number742719
JournalInternational Journal of Endocrinology
StatePublished - Oct 11 2011


ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Endocrine and Autonomic Systems

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