Abstract
Depression accelerates the development and progression of cardiovascular disease and confers an increased risk of mortality. Platelets share biochemical similarity with the central nervous system, particularly in the uptake, storage, and metabolism of serotonin. Given this similarity, and considering the central role of platelets in the biology of cardiovascular disease, it is highly plausible that platelets play an important role in the increased cardiovascular risk of patients with depression. This article provides a comprehensive review of the evidence in this area and shows that the relationship between depression and platelet function is hardly straightforward. Whereas many studies have found that patients with depression have exaggerated platelet activation, quite a number of others show no such relationship or even lower levels of platelet activation in patients with depression. Larger, carefully designed, adequately powered studies with standardized methods of assessing platelet function are needed to address this issue.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 612-617 |
| Number of pages | 6 |
| Journal | Southern Medical Journal |
| Volume | 101 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jun 2008 |
| Externally published | Yes |
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Keywords
- Cardiovascular diseases
- Depression
- Platelets
- Selective serotonin reuptake inhibitor
- Serotonin
ASJC Scopus subject areas
- Medicine(all)
Cite this
Platelet function in patients with depression. / Parakh, Kapil; Sakhuja, Ankit; Bhat, Utsav; Ziegelstein, Roy.
In: Southern Medical Journal, Vol. 101, No. 6, 06.2008, p. 612-617.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Platelet function in patients with depression
AU - Parakh, Kapil
AU - Sakhuja, Ankit
AU - Bhat, Utsav
AU - Ziegelstein, Roy
PY - 2008/6
Y1 - 2008/6
N2 - Depression accelerates the development and progression of cardiovascular disease and confers an increased risk of mortality. Platelets share biochemical similarity with the central nervous system, particularly in the uptake, storage, and metabolism of serotonin. Given this similarity, and considering the central role of platelets in the biology of cardiovascular disease, it is highly plausible that platelets play an important role in the increased cardiovascular risk of patients with depression. This article provides a comprehensive review of the evidence in this area and shows that the relationship between depression and platelet function is hardly straightforward. Whereas many studies have found that patients with depression have exaggerated platelet activation, quite a number of others show no such relationship or even lower levels of platelet activation in patients with depression. Larger, carefully designed, adequately powered studies with standardized methods of assessing platelet function are needed to address this issue.
AB - Depression accelerates the development and progression of cardiovascular disease and confers an increased risk of mortality. Platelets share biochemical similarity with the central nervous system, particularly in the uptake, storage, and metabolism of serotonin. Given this similarity, and considering the central role of platelets in the biology of cardiovascular disease, it is highly plausible that platelets play an important role in the increased cardiovascular risk of patients with depression. This article provides a comprehensive review of the evidence in this area and shows that the relationship between depression and platelet function is hardly straightforward. Whereas many studies have found that patients with depression have exaggerated platelet activation, quite a number of others show no such relationship or even lower levels of platelet activation in patients with depression. Larger, carefully designed, adequately powered studies with standardized methods of assessing platelet function are needed to address this issue.
KW - Cardiovascular diseases
KW - Depression
KW - Platelets
KW - Selective serotonin reuptake inhibitor
KW - Serotonin
UR - http://www.scopus.com/inward/record.url?scp=45149086033&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=45149086033&partnerID=8YFLogxK
U2 - 10.1097/SMJ.0b013e318172f732
DO - 10.1097/SMJ.0b013e318172f732
M3 - Article
C2 - 18475223
AN - SCOPUS:45149086033
VL - 101
SP - 612
EP - 617
JO - Southern Medical Journal
JF - Southern Medical Journal
SN - 0038-4348
IS - 6
ER -