Abstract
Platelet endothelial cell adhesion molecule (PECAM-1) is a member of the superfamily of immunoglobulins. This cell adhesion molecule has been implicated to mediate the adhesion and trans-endothelial migration of T lymphocytes/monocytes into the vascular wall, a critical step in the initiation of atherogenesis. Current thinking, however, posits that PECAM-1 by virtue of being a scaffolding molecule may well play a role in several signal transduction reactions. As a consequence, this cell adhesion molecule may be responsible for several biological and pathophysiological functions such as thrombosis, and inflammation. Evidence has also been put forward for a potential role of PECAM-1 in apoptosis and atherosclerosis. This article focuses on the structure of PECAM-1 and its role in intracellular signaling and implications in health and disease.
Original language | English (US) |
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Pages (from-to) | 151-158 |
Number of pages | 8 |
Journal | Molecular and Cellular Biochemistry |
Volume | 253 |
Issue number | 1-2 |
DOIs | |
State | Published - Nov 1 2003 |
Keywords
- Atherosclerosis
- Cell adhesion and trans-endothelial migration
- Inflammation
- Intracellular signaling
- PECAM-1
- Regulation
- Structure
- Thrombosis
ASJC Scopus subject areas
- Molecular Biology
- Clinical Biochemistry
- Cell Biology