Platelet endothelial cell adhesion molecule in cell signaling and thrombosis

Nan Ling Gong, Subroto Chatterjee

Research output: Contribution to journalReview article

Abstract

Platelet endothelial cell adhesion molecule (PECAM-1) is a member of the superfamily of immunoglobulins. This cell adhesion molecule has been implicated to mediate the adhesion and trans-endothelial migration of T lymphocytes/monocytes into the vascular wall, a critical step in the initiation of atherogenesis. Current thinking, however, posits that PECAM-1 by virtue of being a scaffolding molecule may well play a role in several signal transduction reactions. As a consequence, this cell adhesion molecule may be responsible for several biological and pathophysiological functions such as thrombosis, and inflammation. Evidence has also been put forward for a potential role of PECAM-1 in apoptosis and atherosclerosis. This article focuses on the structure of PECAM-1 and its role in intracellular signaling and implications in health and disease.

Original languageEnglish (US)
Pages (from-to)151-158
Number of pages8
JournalMolecular and Cellular Biochemistry
Volume253
Issue number1-2
DOIs
StatePublished - Nov 1 2003

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Keywords

  • Atherosclerosis
  • Cell adhesion and trans-endothelial migration
  • Inflammation
  • Intracellular signaling
  • PECAM-1
  • Regulation
  • Structure
  • Thrombosis

ASJC Scopus subject areas

  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

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