Platelet-Derived Growth Factor is Chemotactic for Human Retinal Pigment Epithelial Cells

Peter A. Campochiaro; Bert M. Glaser

doi:10.1001/archopht.1985.01050040118034

Platelet-Derived Growth Factor is Chemotactic for Human Retinal Pigment Epithelial Cells

Peter A. Campochiaro, Bert M. Glaser

School of Medicine

Research output: Contribution to journal › Article › peer-review

143 Scopus citations

Abstract

The presence of blood or serum in the vitreous cavity has been associated with the formation of cellular membranes in proliferative vitreoretinopathy and after penetrating ocular trauma. Retinal pigment epithelial (RPE) cells are an important component of these membranes. For RPE cells to effectively spread throughout the vitreous cavity and form contractile membranes, cell migration must occur. Serum has been shown to initiate RPE cell migration. Fibronectin (FN), a glycoprotein found in serum, stimulates RPE cell migration but accounts for only part of the stimulatory effect of serum. We report that another serum component, platelet-derived growth factor (PDGF), also stimulates RPE cell migration. Furthermore, the effect of PDGF and FN are additive and together probably account for a large part of the chemotactic activity found in serum.

Original language	English (US)
Pages (from-to)	576-579
Number of pages	4
Journal	Archives of ophthalmology
Volume	103
Issue number	4
DOIs	https://doi.org/10.1001/archopht.1985.01050040118034
State	Published - Apr 1985

ASJC Scopus subject areas

Ophthalmology

Access to Document

10.1001/archopht.1985.01050040118034

Cite this

@article{a06226203e7a4d1da1652c866177e705,

title = "Platelet-Derived Growth Factor is Chemotactic for Human Retinal Pigment Epithelial Cells",

abstract = "The presence of blood or serum in the vitreous cavity has been associated with the formation of cellular membranes in proliferative vitreoretinopathy and after penetrating ocular trauma. Retinal pigment epithelial (RPE) cells are an important component of these membranes. For RPE cells to effectively spread throughout the vitreous cavity and form contractile membranes, cell migration must occur. Serum has been shown to initiate RPE cell migration. Fibronectin (FN), a glycoprotein found in serum, stimulates RPE cell migration but accounts for only part of the stimulatory effect of serum. We report that another serum component, platelet-derived growth factor (PDGF), also stimulates RPE cell migration. Furthermore, the effect of PDGF and FN are additive and together probably account for a large part of the chemotactic activity found in serum.",

author = "Campochiaro, {Peter A.} and Glaser, {Bert M.}",

year = "1985",

month = apr,

doi = "10.1001/archopht.1985.01050040118034",

language = "English (US)",

volume = "103",

pages = "576--579",

journal = "Archives of ophthalmology",

issn = "0003-9950",

publisher = "American Medical Association",

number = "4",

}

TY - JOUR

T1 - Platelet-Derived Growth Factor is Chemotactic for Human Retinal Pigment Epithelial Cells

AU - Campochiaro, Peter A.

AU - Glaser, Bert M.

PY - 1985/4

Y1 - 1985/4

N2 - The presence of blood or serum in the vitreous cavity has been associated with the formation of cellular membranes in proliferative vitreoretinopathy and after penetrating ocular trauma. Retinal pigment epithelial (RPE) cells are an important component of these membranes. For RPE cells to effectively spread throughout the vitreous cavity and form contractile membranes, cell migration must occur. Serum has been shown to initiate RPE cell migration. Fibronectin (FN), a glycoprotein found in serum, stimulates RPE cell migration but accounts for only part of the stimulatory effect of serum. We report that another serum component, platelet-derived growth factor (PDGF), also stimulates RPE cell migration. Furthermore, the effect of PDGF and FN are additive and together probably account for a large part of the chemotactic activity found in serum.

AB - The presence of blood or serum in the vitreous cavity has been associated with the formation of cellular membranes in proliferative vitreoretinopathy and after penetrating ocular trauma. Retinal pigment epithelial (RPE) cells are an important component of these membranes. For RPE cells to effectively spread throughout the vitreous cavity and form contractile membranes, cell migration must occur. Serum has been shown to initiate RPE cell migration. Fibronectin (FN), a glycoprotein found in serum, stimulates RPE cell migration but accounts for only part of the stimulatory effect of serum. We report that another serum component, platelet-derived growth factor (PDGF), also stimulates RPE cell migration. Furthermore, the effect of PDGF and FN are additive and together probably account for a large part of the chemotactic activity found in serum.

UR - http://www.scopus.com/inward/record.url?scp=0021957738&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021957738&partnerID=8YFLogxK

U2 - 10.1001/archopht.1985.01050040118034

DO - 10.1001/archopht.1985.01050040118034

M3 - Article

C2 - 3985844

AN - SCOPUS:0021957738

SN - 0003-9950

VL - 103

SP - 576

EP - 579

JO - Archives of ophthalmology

JF - Archives of ophthalmology

IS - 4

ER -

Platelet-Derived Growth Factor is Chemotactic for Human Retinal Pigment Epithelial Cells

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this