TY - JOUR
T1 - Platelet derived growth factor inhibitors
T2 - A potential therapeutic approach for ocular neovascularization
AU - Sadiq, Mohammad Ali
AU - Hanout, Mostafa
AU - Sarwar, Salman
AU - Hassan, Muhammad
AU - Do, Diana V.
AU - Nguyen, Quan Dong
AU - Sepah, Yasir Jamal
N1 - Publisher Copyright:
© 2015 The Authors.
Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 2015
Y1 - 2015
N2 - Retinochoroidal vascular diseases are the leading causes of blindness in the developed world. They include diabetic retinopathy (DR), retinal vein occlusion, retinopathy of prematurity, age-related macular degeneration (AMD), and pathological myopia, among many others. Several different therapies are currently under consideration for the aforementioned disorders. In the following section, agents targeting platelet-derived growth factor (PDGF) are discussed as a potential therapeutic option for retinochoroidal vascular diseases. PDGF plays an important role in the angiogenesis cascade that is activated in retinochoroidal vascular diseases. The mechanism of action, side effects, efficacy, and the potential synergistic role of these agents in combination with other treatment options is discussed. The future of treatment of retinochoroidal vascular diseases, particularly AMD, has become more exciting due to agents such as PDGF antagonists.
AB - Retinochoroidal vascular diseases are the leading causes of blindness in the developed world. They include diabetic retinopathy (DR), retinal vein occlusion, retinopathy of prematurity, age-related macular degeneration (AMD), and pathological myopia, among many others. Several different therapies are currently under consideration for the aforementioned disorders. In the following section, agents targeting platelet-derived growth factor (PDGF) are discussed as a potential therapeutic option for retinochoroidal vascular diseases. PDGF plays an important role in the angiogenesis cascade that is activated in retinochoroidal vascular diseases. The mechanism of action, side effects, efficacy, and the potential synergistic role of these agents in combination with other treatment options is discussed. The future of treatment of retinochoroidal vascular diseases, particularly AMD, has become more exciting due to agents such as PDGF antagonists.
KW - Age related macular degeneration
KW - Diabetic retinopathy
KW - PDGF
KW - Platelet derived growth factor
KW - Retinal vascular disease
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U2 - 10.1016/j.sjopt.2015.05.005
DO - 10.1016/j.sjopt.2015.05.005
M3 - Review article
C2 - 26586980
AN - SCOPUS:84952873484
VL - 29
SP - 287
EP - 291
JO - Saudi Journal of Ophthalmology
JF - Saudi Journal of Ophthalmology
SN - 1319-4534
IS - 4
ER -