Platelet activation in myocardial ischemic syndromes

Paul A. Gurbel, Kevin P. Bliden, Kevin M. Hayes, Udaya Tantry

Research output: Contribution to journalReview article


Platelets play a central role in the pathogenesis of atherosclerois and thrombosis. Platelet adhesion and aggregate formation are critical events that occur in unstable coronary syndromes. Platelet activation precedes the formation of homotypic and heterotypic aggregates. In the last 10 years, researchers have described the presence of activated platelets in the systemic circulation in various cardiovascular disease states, particularly acute coronary syndromes. This review describes the evidence for platelet activation in acute myocardial ischemic syndromes, describes the pathophysiology responsible for its occurrence, and discusses how platelet activation and reactivity may affect the use of concomitant drug therapies and patient prognosis.

Original languageEnglish (US)
Pages (from-to)535-545
Number of pages11
JournalExpert review of cardiovascular therapy
Issue number4
StatePublished - Jul 1 2004


  • Acute coronary syndrome
  • Aggregation
  • Flow cytometry
  • Myocardial ischemia
  • Platelet activation
  • Platelet reactivity
  • Platelets
  • Receptors

ASJC Scopus subject areas

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine

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