Abstract
Background: PAF has been implicated as a potent lipid mediator of endotoxin-induced sepsis, but its role in anthraxassociated shock is unknown. Results: Increased serum levels of PAF were present in LeTx-challenged mice. Inhibition of PAF activity prolonged survival ameliorated increased vascular permeability and hepatic necrosis. Conclusion: PAF appears to be a mediator in lethal toxin-associated damage. Significance: PAF antagonists may be helpful as adjunctive therapy for anthrax-associated shock.
Original language | English (US) |
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Pages (from-to) | 7131-7141 |
Number of pages | 11 |
Journal | Journal of Biological Chemistry |
Volume | 289 |
Issue number | 10 |
DOIs | |
State | Published - Mar 7 2014 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology