Abstract
Coughing serves to clear the airways of inhaled particulate matter, aspirate and other noxious stimuli, and is therefore necessary for the maintenance of normal airway function. The cough reflex, however, can become excessive and inappropriate during exacerbations of many airways diseases. This plasticity of the cough reflex is due to changes in the sensitivity of the neural pathways regulating cough. Understanding the mechanisms leading to heightened cough sensitivity is essential for the successful treatment of cough disorders. The aim of this review is to discuss potential mechanisms underlying cough plasticity during disease.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 236-242 |
| Number of pages | 7 |
| Journal | European Respiratory Review |
| Volume | 12 |
| Issue number | 85 |
| State | Published - Dec 2002 |
Fingerprint
Keywords
- C-Fibre
- Inflammation
- Neurokinin
- Rapidly adapting receptor
- Sensitisation
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
Cite this
Plasticity of the cough reflex. / Mazzone, S. B.; Canning, Brendan J.
In: European Respiratory Review, Vol. 12, No. 85, 12.2002, p. 236-242.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Plasticity of the cough reflex
AU - Mazzone, S. B.
AU - Canning, Brendan J
PY - 2002/12
Y1 - 2002/12
N2 - Coughing serves to clear the airways of inhaled particulate matter, aspirate and other noxious stimuli, and is therefore necessary for the maintenance of normal airway function. The cough reflex, however, can become excessive and inappropriate during exacerbations of many airways diseases. This plasticity of the cough reflex is due to changes in the sensitivity of the neural pathways regulating cough. Understanding the mechanisms leading to heightened cough sensitivity is essential for the successful treatment of cough disorders. The aim of this review is to discuss potential mechanisms underlying cough plasticity during disease.
AB - Coughing serves to clear the airways of inhaled particulate matter, aspirate and other noxious stimuli, and is therefore necessary for the maintenance of normal airway function. The cough reflex, however, can become excessive and inappropriate during exacerbations of many airways diseases. This plasticity of the cough reflex is due to changes in the sensitivity of the neural pathways regulating cough. Understanding the mechanisms leading to heightened cough sensitivity is essential for the successful treatment of cough disorders. The aim of this review is to discuss potential mechanisms underlying cough plasticity during disease.
KW - C-Fibre
KW - Inflammation
KW - Neurokinin
KW - Rapidly adapting receptor
KW - Sensitisation
UR - http://www.scopus.com/inward/record.url?scp=0037675122&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037675122&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0037675122
VL - 12
SP - 236
EP - 242
JO - European Respiratory Review
JF - European Respiratory Review
SN - 0905-9180
IS - 85
ER -