Plasticity of the cough reflex

S. B. Mazzone; B. J. Canning

Plasticity of the cough reflex

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Coughing serves to clear the airways of inhaled particulate matter, aspirate and other noxious stimuli, and is therefore necessary for the maintenance of normal airway function. The cough reflex, however, can become excessive and inappropriate during exacerbations of many airways diseases. This plasticity of the cough reflex is due to changes in the sensitivity of the neural pathways regulating cough. Understanding the mechanisms leading to heightened cough sensitivity is essential for the successful treatment of cough disorders. The aim of this review is to discuss potential mechanisms underlying cough plasticity during disease.

Original language	English (US)
Pages (from-to)	236-242
Number of pages	7
Journal	European Respiratory Review
Volume	12
Issue number	85
State	Published - Dec 1 2002

Keywords

C-Fibre
Inflammation
Neurokinin
Rapidly adapting receptor
Sensitisation

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine

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N2 - Coughing serves to clear the airways of inhaled particulate matter, aspirate and other noxious stimuli, and is therefore necessary for the maintenance of normal airway function. The cough reflex, however, can become excessive and inappropriate during exacerbations of many airways diseases. This plasticity of the cough reflex is due to changes in the sensitivity of the neural pathways regulating cough. Understanding the mechanisms leading to heightened cough sensitivity is essential for the successful treatment of cough disorders. The aim of this review is to discuss potential mechanisms underlying cough plasticity during disease.

AB - Coughing serves to clear the airways of inhaled particulate matter, aspirate and other noxious stimuli, and is therefore necessary for the maintenance of normal airway function. The cough reflex, however, can become excessive and inappropriate during exacerbations of many airways diseases. This plasticity of the cough reflex is due to changes in the sensitivity of the neural pathways regulating cough. Understanding the mechanisms leading to heightened cough sensitivity is essential for the successful treatment of cough disorders. The aim of this review is to discuss potential mechanisms underlying cough plasticity during disease.

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KW - Inflammation

KW - Neurokinin

KW - Rapidly adapting receptor

KW - Sensitisation

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Plasticity of the cough reflex

Abstract

Keywords

ASJC Scopus subject areas

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