Plasmodium sporozoite invasion of the mosquito salivary gland

Anil Kumar Ghosh, Marcelo Jacobs-Lorena

Research output: Contribution to journalReview articlepeer-review

Abstract

About one to two million people die of malaria every year. Anopheline mosquitoes are the obligatory vectors of Plasmodium spp., the causative agent of malaria. For transmission to occur, the parasite has to undergo a complex developmental programme in the mosquito, culminating with sporozoite invasion of the salivary glands. Strong circumstantial evidence suggests that sporozoite invasion requires specific interactions and recognition between sporozoite and salivary gland proteins. Here we review recent progress towards the elucidation of invasion mechanisms.

Original languageEnglish (US)
Pages (from-to)394-400
Number of pages7
JournalCurrent Opinion in Microbiology
Volume12
Issue number4
DOIs
StatePublished - Aug 1 2009

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases

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