TY - JOUR
T1 - Plasmodium sporozoite invasion of the mosquito salivary gland
AU - Ghosh, Anil Kumar
AU - Jacobs-Lorena, Marcelo
N1 - Funding Information:
We thank Photini Sinnis and an anonymous reviewer for excellent comments that helped improve the manuscript. Work in our laboratory was supported by grants from the National Institutes of Health.
PY - 2009/8
Y1 - 2009/8
N2 - About one to two million people die of malaria every year. Anopheline mosquitoes are the obligatory vectors of Plasmodium spp., the causative agent of malaria. For transmission to occur, the parasite has to undergo a complex developmental programme in the mosquito, culminating with sporozoite invasion of the salivary glands. Strong circumstantial evidence suggests that sporozoite invasion requires specific interactions and recognition between sporozoite and salivary gland proteins. Here we review recent progress towards the elucidation of invasion mechanisms.
AB - About one to two million people die of malaria every year. Anopheline mosquitoes are the obligatory vectors of Plasmodium spp., the causative agent of malaria. For transmission to occur, the parasite has to undergo a complex developmental programme in the mosquito, culminating with sporozoite invasion of the salivary glands. Strong circumstantial evidence suggests that sporozoite invasion requires specific interactions and recognition between sporozoite and salivary gland proteins. Here we review recent progress towards the elucidation of invasion mechanisms.
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U2 - 10.1016/j.mib.2009.06.010
DO - 10.1016/j.mib.2009.06.010
M3 - Review article
C2 - 19608457
AN - SCOPUS:68049117073
SN - 1369-5274
VL - 12
SP - 394
EP - 400
JO - Current Opinion in Microbiology
JF - Current Opinion in Microbiology
IS - 4
ER -