Plasmodium sporozoite-host interactions from the dermis to the hepatocyte

Ijeoma Ejigiri, Photini Sinnis

Research output: Contribution to journalArticle

Abstract

Sporozoites are the infective stage of the malaria parasite. They are deposited in the skin by infected Anopheles mosquitoes and must penetrate cell barriers in the skin and liver sinusoid to reach their target cell, the hepatocyte, where they enter in a vacuole and begin development into the next life cycle stage, the exoerythrocytic form. Recent advances in our understanding of sporozoite biology in the dermal inoculation site, the role of cell traversal and the mechanism by which sporozoites productively invade hepatocytes will be highlighted in this review.

Original languageEnglish (US)
Pages (from-to)401-407
Number of pages7
JournalCurrent Opinion in Microbiology
Volume12
Issue number4
DOIs
StatePublished - Aug 2009
Externally publishedYes

Fingerprint

Sporozoites
Plasmodium
Dermis
Hepatocytes
Skin
Anopheles
Vacuoles
Life Cycle Stages
Culicidae
Malaria
Parasites
Liver

ASJC Scopus subject areas

  • Infectious Diseases
  • Microbiology (medical)
  • Microbiology

Cite this

Plasmodium sporozoite-host interactions from the dermis to the hepatocyte. / Ejigiri, Ijeoma; Sinnis, Photini.

In: Current Opinion in Microbiology, Vol. 12, No. 4, 08.2009, p. 401-407.

Research output: Contribution to journalArticle

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