Plasmodium-mosquito interactions, phage display libraries and transgenic mosquitoes impaired for malaria transmission

A. K. Ghosh, L. A. Moreira, M. Jacobs-Lorena

Research output: Contribution to journalArticlepeer-review

Abstract

Malaria continues to kill millions of people every year and new strategies to combat this disease are urgently needed. Recent advances in the study of the mosquito vector and its interactions with the malaria parasite suggest that it may be possible to genetically manipulate the mosquito in order to reduce its vectorial capacity. Here we review the advances made to date in four areas: (1) the introduction of foreign genes into the mosquito germ line; (2) the characterization of tissue-specific promoters; (3) the identification of gene products that block development of the parasite in the mosquito; and (4) the generation of transgenic mosquitoes impaired for malaria transmission. While initial results show great promise, the problem of how to spread the blocking genes through wild mosquito populations remains to be solved.

Original languageEnglish (US)
Pages (from-to)1325-1331
Number of pages7
JournalInsect Biochemistry and Molecular Biology
Volume32
Issue number10
DOIs
StatePublished - Oct 2002

Keywords

  • Malaria
  • Plasmodium
  • Transgenic mosquitoes
  • Transmission blocking

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Insect Science

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