Plasmodium-Mosquito Interactions. A Tale of Roadblocks and Detours

Ryan C. Smith, Marcelo Jacobs-Lorena

Research output: Book/ReportBook

Abstract

Mosquitoes serve as the obligate vectors for the transmission of malaria parasites. During its sexual life cycle within the mosquito, the parasite must undergo several morphological changes and overcome developmental bottlenecks to ensure its successful transmission to a new vertebrate host. Here we review our current understanding of the molecular interactions that occur between Plasmodium parasites and its mosquito (Genus: Anopheles) host, from the initial uptake of gametocytes in the blood meal to the delivery of sporozoites through the bite of the mosquito. By reviewing our understanding of the physical and molecular barriers that the parasite must evade and endure, we hope to capitalize upon our knowledge to develop strategies to interfere with malaria transmission.

Original languageEnglish (US)
PublisherUnknown Publisher
Number of pages31
Volume39
EditionC
DOIs
StatePublished - 2010

Publication series

NameAdvances in Insect Physiology
No.C
Volume39
ISSN (Print)00652806

Fingerprint

Plasmodium
Culicidae
parasites
malaria
mosquito bites
gametocytes
Anopheles
sporozoites
blood meal
life cycle (organisms)
vertebrates
uptake mechanisms

Keywords

  • Host-parasite interactions
  • Malaria
  • Mosquito
  • Plasmodium

ASJC Scopus subject areas

  • Insect Science

Cite this

Smith, R. C., & Jacobs-Lorena, M. (2010). Plasmodium-Mosquito Interactions. A Tale of Roadblocks and Detours. (C ed.) (Advances in Insect Physiology; Vol. 39, No. C). Unknown Publisher. https://doi.org/10.1016/B978-0-12-381387-9.00004-X

Plasmodium-Mosquito Interactions. A Tale of Roadblocks and Detours. / Smith, Ryan C.; Jacobs-Lorena, Marcelo.

C ed. Unknown Publisher, 2010. 31 p. (Advances in Insect Physiology; Vol. 39, No. C).

Research output: Book/ReportBook

Smith, RC & Jacobs-Lorena, M 2010, Plasmodium-Mosquito Interactions. A Tale of Roadblocks and Detours. Advances in Insect Physiology, no. C, vol. 39, vol. 39, C edn, Unknown Publisher. https://doi.org/10.1016/B978-0-12-381387-9.00004-X
Smith, Ryan C. ; Jacobs-Lorena, Marcelo. / Plasmodium-Mosquito Interactions. A Tale of Roadblocks and Detours. C ed. Unknown Publisher, 2010. 31 p. (Advances in Insect Physiology; C).
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