Plasmodium-Mosquito Interactions. A Tale of Roadblocks and Detours

Ryan C. Smith, Marcelo Jacobs-Lorena

Research output: Contribution to journalArticle

Abstract

Mosquitoes serve as the obligate vectors for the transmission of malaria parasites. During its sexual life cycle within the mosquito, the parasite must undergo several morphological changes and overcome developmental bottlenecks to ensure its successful transmission to a new vertebrate host. Here we review our current understanding of the molecular interactions that occur between Plasmodium parasites and its mosquito (Genus: Anopheles) host, from the initial uptake of gametocytes in the blood meal to the delivery of sporozoites through the bite of the mosquito. By reviewing our understanding of the physical and molecular barriers that the parasite must evade and endure, we hope to capitalize upon our knowledge to develop strategies to interfere with malaria transmission.

Original languageEnglish (US)
Pages (from-to)119-149
Number of pages31
JournalAdvances in Insect Physiology
Volume39
Issue numberC
DOIs
StatePublished - Oct 21 2010

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Keywords

  • Host-parasite interactions
  • Malaria
  • Mosquito
  • Plasmodium

ASJC Scopus subject areas

  • Insect Science

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