@article{4af6d992b1ee4fac9b4f682358fe1ec6,
title = "Plasmodium, human, and Anopheles genomics and malaria",
abstract = "The Plasmodium spp. parasites that cause malaria are transmitted to humans by Anopheles spp. mosquitoes. Scientists have now amassed a great body of knowledge about the parasite, its mosquito vector and human host. Yet this year there will be 300-500 million new malaria infections and 1-3 million deaths caused by the disease. We believe that integrated analyses of genome sequence, DNA polymorphisms, and messenger RNA and protein expression profiles will lead to greater understanding of the molecular basis of vector-human and host-parasite interactions and provide strategies to build upon these insights to develop interventions to mitigate human morbidity and mortality from malaria.",
author = "Hoffman, {Stephen L.} and Subramanian, {G. Mani} and Collins, {Frank H.} and Venter, {J. Craig}",
note = "Funding Information: The A. gambiae genome project is funded largely by the National Institute of Allergy and Infectious Diseases and the French Government, with the World Health Organization/Tropical Disease Research programme providing a coordinating role and assisting in database development. Celera Genomics and G{\'e}noscope have recently completed a shotgun sequencing effort (102 coverage), which has been assembled by Celera. Two independent annotations, one by Celera and the other by the European Bioinformatics Institute using Ensembl should be completed by early 2002. The annotated genome may be presented publicly as early as March 2002 either through Ensembl or through an adapted version of the Drosophila GadFly. End sequences of two different A. gambiae bacterial artificial chromosome (BAC) libraries (>102 coverage), the physical map location of ~2,000 BAC clones, perhaps as many as 80,000 ESTs, and several sequenced and annotated genomic DNA contigs (100–500+ kb) will facilitate assembly and annotation. Celera Genomics, the European Molecular Biology Laboratory, G{\'e}noscope, the Institute of Molecular Biology and Biotechnology in Crete, the Institut Pasteur in Paris, TIGR, and the Universities of Iowa, Rome and Notre Dame are contributing.",
year = "2002",
month = feb,
day = "7",
doi = "10.1038/415702a",
language = "English (US)",
volume = "415",
pages = "702--709",
journal = "Nature",
issn = "0028-0836",
publisher = "Nature Publishing Group",
number = "6872",
}