TY - JOUR
T1 - Plasmodium falciparum merozoite surface protein 1 blocks the proinflammatory protein S100P
AU - Waisberg, Michael
AU - Cerqueira, Gustavo C.
AU - Yager, Stephanie B.
AU - Francischetti, Ivo M.B.
AU - Lu, Jinghua
AU - Gera, Nidhi
AU - Srinivasan, Prakash
AU - Miura, Kazutoyo
AU - Rada, Balazs
AU - Lukszo, Jan
AU - Barbian, Kent D.
AU - Leto, Thomas L.
AU - Porcella, Stephen F.
AU - Narum, David L.
AU - El-Sayed, Najib
AU - Miller, Louis H.
AU - Pierce, Susan K.
PY - 2012/4/3
Y1 - 2012/4/3
N2 - Themalaria parasite, Plasmodiumfalciparum, and the human immune system have coevolved to ensure that the parasite is not eliminated and reinfection is not resisted. This relationship is likely mediated through a myriad of host-parasite interactions, although surprisingly few such interactions have been identified.Herewe showthat the 33-kDa fragment of P. falciparum merozoite surface protein 1 (MSP1 33), an abundant protein that is shed during red blood cell invasion, binds to the proinflammatory protein, S100P. MSP1 33 blocks S100P-induced NFκB activation inmonocytes and chemotaxis in neutrophils. Remarkably, S100P binds to both dimorphic alleles of MSP1, estimated to have diverged >27 Mya, suggesting an ancient, conserved relationship between these parasite and host proteins that may serve to attenuate potentially damaging inflammatory responses.
AB - Themalaria parasite, Plasmodiumfalciparum, and the human immune system have coevolved to ensure that the parasite is not eliminated and reinfection is not resisted. This relationship is likely mediated through a myriad of host-parasite interactions, although surprisingly few such interactions have been identified.Herewe showthat the 33-kDa fragment of P. falciparum merozoite surface protein 1 (MSP1 33), an abundant protein that is shed during red blood cell invasion, binds to the proinflammatory protein, S100P. MSP1 33 blocks S100P-induced NFκB activation inmonocytes and chemotaxis in neutrophils. Remarkably, S100P binds to both dimorphic alleles of MSP1, estimated to have diverged >27 Mya, suggesting an ancient, conserved relationship between these parasite and host proteins that may serve to attenuate potentially damaging inflammatory responses.
KW - High-throughput screen
KW - Placental
KW - Surface plasmon resonance
KW - Yeast two-hybrid
UR - http://www.scopus.com/inward/record.url?scp=84859463461&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84859463461&partnerID=8YFLogxK
U2 - 10.1073/pnas.1202689109
DO - 10.1073/pnas.1202689109
M3 - Article
C2 - 22431641
AN - SCOPUS:84859463461
SN - 0027-8424
VL - 109
SP - 5429
EP - 5434
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 14
ER -