Plasmodium falciparum glycosylphosphatidylinositol induces limited apoptosis in liver and spleen mouse tissue

Dominic Wichmann, Ralph T. Schwarz, Volker Ruppert, Stephan Ehrhardt, Jakob P. Cramer, Gerd D. Burchard, Bernhard Maisch, Françoise Debierre-Grockiego

Research output: Contribution to journalArticlepeer-review

Abstract

Plasmodium falciparum malaria affects about 500 million people worldwide and is responsible for approximately 2.5 million deaths per year. Glycosylphosphatidylinositol (GPI) is the major anchor for membrane-associated proteins of P. falciparum and GPI plays a major role as a toxin in the pathology of malaria. Therefore, we tested the hypothesis that GPI, like LPS, induces apoptosis in vitro and in vital organs of mice. Our data does not provide evidence for direct cardiomyocyte apoptosis induced by GPI in vitro. However, in vivo injection of GPI induced limited apoptosis in mouse liver and spleen tissue. Apoptosis may be due to a direct GPI apoptotic effect or to an indirect effect via the induction of TNFα and nitric oxide production.

Original languageEnglish (US)
Pages (from-to)1037-1041
Number of pages5
JournalApoptosis
Volume12
Issue number6
DOIs
StatePublished - Jun 1 2007
Externally publishedYes

Keywords

  • Apoptosis
  • Cardiomyocytes
  • GPI
  • Heart
  • Plasmodium

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science
  • Clinical Biochemistry
  • Cell Biology
  • Biochemistry, medical
  • Cancer Research

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