Plasmodium falciparum: Detection of a novel asparagine-rich protein on the surface of sporozoite

Kunyan Zhang, Hisashi Fujioka, Masamichi Aikawa, Nirbhay Kumar

Research output: Contribution to journalArticle

Abstract

We had previously cloned and characterized a gene for a novel asparagine-rich protein from P falciparum (PfARP), a target of natural human immune response. The antibodies to PfARP were localized to the surface of parasitized red blood cells and reacted with intracellular components in all erythrocytic asexual and sexual stages of the parasite. We here describe reactivity of antibodies against this novel PfARP on the surface of mosquito stage sporozoite of P. falciparum by indirect immunofluorescence assay and immunoelectron microscopy, the latter revealing a highly periodic punctate pattern of distribution of PfARP on the surface of sporozoite. These results suggest a possibility that PfARP might represent yet another sporozoite surface protein.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalExperimental Parasitology
Volume93
Issue number1
DOIs
StatePublished - Sep 1999

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ASJC Scopus subject areas

  • Parasitology
  • Immunology
  • Infectious Diseases

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