Plasmodium falciparum ATG8 implicated in both autophagy and apicoplast formation

Andrew M. Tomlins; Fathia Ben-Rached; Roderick AM Williams; William R. Proto; Isabelle Coppens; Ulrike Ruch; Tim W. Gilberger; Graham H. Coombs; Jeremy C. Mottram; Sylke Müller; Gordon Langsley

doi:10.4161/auto.25832

Plasmodium falciparum ATG8 implicated in both autophagy and apicoplast formation

Andrew M. Tomlins, Fathia Ben-Rached, Roderick AM Williams, William R. Proto, Isabelle Coppens, Ulrike Ruch, Tim W. Gilberger, Graham H. Coombs, Jeremy C. Mottram, Sylke Müller, Gordon Langsley

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

Abstract

APE1, vacuolar aminopeptidase 1; ATG, autophagy-related (gene); ATG, autophagy-related (protein); ATG8-I, ATG4-cleaved form of ATG8; ATG8-II, lipidated form of ATG8; CDS, coding sequence; GFP, green fluorescence protein; IPP, isopentenyl-pyrophosphate; mCherry, mCherry fluorescence protein; PE, phosphatidylethanolamine; PfATG8, Plasmodium falciparum ATG8; PfATG8?G, PfATG8 lacking the C-terminal glycine residue; PfATG3, P. falciparum ATG3; aLipDH-GFP, apicoplast lipoamide dehydrogenase-GFP; mLipDH-GFP, mitochondrial lipoamide dehydrogenase- GFP; LmATG12, Leishmania major ATG12; mAPE1, mature form of vacuolar aminopeptidase 1; pAPE1, precursor form.

Original language	English (US)
Pages (from-to)	1540-1552
Number of pages	13
Journal	Autophagy
Volume	9
Issue number	10
DOIs	https://doi.org/10.4161/auto.25832
State	Published - Oct 2013

Keywords

ATG8
Apicoplast
Autophagy
Endosome
Food vacuole
Malaria
Plasmodium
RAB7

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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Plasmodium falciparum ATG8 implicated in both autophagy and apicoplast formation. / Tomlins, Andrew M.; Ben-Rached, Fathia; Williams, Roderick AM; Proto, William R.; Coppens, Isabelle; Ruch, Ulrike; Gilberger, Tim W.; Coombs, Graham H.; Mottram, Jeremy C.; Müller, Sylke; Langsley, Gordon.

In: Autophagy, Vol. 9, No. 10, 10.2013, p. 1540-1552.

Research output: Contribution to journal › Article › peer-review

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title = "Plasmodium falciparum ATG8 implicated in both autophagy and apicoplast formation",

abstract = "APE1, vacuolar aminopeptidase 1; ATG, autophagy-related (gene); ATG, autophagy-related (protein); ATG8-I, ATG4-cleaved form of ATG8; ATG8-II, lipidated form of ATG8; CDS, coding sequence; GFP, green fluorescence protein; IPP, isopentenyl-pyrophosphate; mCherry, mCherry fluorescence protein; PE, phosphatidylethanolamine; PfATG8, Plasmodium falciparum ATG8; PfATG8?G, PfATG8 lacking the C-terminal glycine residue; PfATG3, P. falciparum ATG3; aLipDH-GFP, apicoplast lipoamide dehydrogenase-GFP; mLipDH-GFP, mitochondrial lipoamide dehydrogenase- GFP; LmATG12, Leishmania major ATG12; mAPE1, mature form of vacuolar aminopeptidase 1; pAPE1, precursor form.",

keywords = "ATG8, Apicoplast, Autophagy, Endosome, Food vacuole, Malaria, Plasmodium, RAB7",

author = "Tomlins, {Andrew M.} and Fathia Ben-Rached and Williams, {Roderick AM} and Proto, {William R.} and Isabelle Coppens and Ulrike Ruch and Gilberger, {Tim W.} and Coombs, {Graham H.} and Mottram, {Jeremy C.} and Sylke M{\"u}ller and Gordon Langsley",

note = "Funding Information: AMT was supported by a BBSRC Doctoral Training Grant (BB/D526329/1); FBR by a Fondation de France PhD fellowship; JCM and GHC by the MRC (G0700127) and UR by the GRK1459 (Deutsche Forschungsgemeinschaft). GL acknowledges support of Inserm, the Cnrs and the Labex ParaFrap ANR-11-LABX-0024. We acknowledge European Community Seventh Framework Programmes FP7 MALSIG (GL) and FP7 N° 242095 (SM) and support by the Wellcome Trust (WT061173MA-SM, WT085349).",

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AU - Tomlins, Andrew M.

AU - Ben-Rached, Fathia

AU - Williams, Roderick AM

AU - Proto, William R.

AU - Coppens, Isabelle

AU - Ruch, Ulrike

AU - Gilberger, Tim W.

AU - Coombs, Graham H.

AU - Mottram, Jeremy C.

AU - Müller, Sylke

AU - Langsley, Gordon

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PY - 2013/10

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N2 - APE1, vacuolar aminopeptidase 1; ATG, autophagy-related (gene); ATG, autophagy-related (protein); ATG8-I, ATG4-cleaved form of ATG8; ATG8-II, lipidated form of ATG8; CDS, coding sequence; GFP, green fluorescence protein; IPP, isopentenyl-pyrophosphate; mCherry, mCherry fluorescence protein; PE, phosphatidylethanolamine; PfATG8, Plasmodium falciparum ATG8; PfATG8?G, PfATG8 lacking the C-terminal glycine residue; PfATG3, P. falciparum ATG3; aLipDH-GFP, apicoplast lipoamide dehydrogenase-GFP; mLipDH-GFP, mitochondrial lipoamide dehydrogenase- GFP; LmATG12, Leishmania major ATG12; mAPE1, mature form of vacuolar aminopeptidase 1; pAPE1, precursor form.

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KW - Food vacuole

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KW - Plasmodium

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