Plasmodium falciparum ATG8 implicated in both autophagy and apicoplast formation

Andrew M. Tomlins, Fathia Ben-Rached, Roderick AM Williams, William R. Proto, Isabelle Coppens, Ulrike Ruch, Tim W. Gilberger, Graham H. Coombs, Jeremy C. Mottram, Sylke Müller, Gordon Langsley

Research output: Contribution to journalArticle

Abstract

APE1, vacuolar aminopeptidase 1; ATG, autophagy-related (gene); ATG, autophagy-related (protein); ATG8-I, ATG4-cleaved form of ATG8; ATG8-II, lipidated form of ATG8; CDS, coding sequence; GFP, green fluorescence protein; IPP, isopentenyl-pyrophosphate; mCherry, mCherry fluorescence protein; PE, phosphatidylethanolamine; PfATG8, Plasmodium falciparum ATG8; PfATG8?G, PfATG8 lacking the C-terminal glycine residue; PfATG3, P. falciparum ATG3; aLipDH-GFP, apicoplast lipoamide dehydrogenase-GFP; mLipDH-GFP, mitochondrial lipoamide dehydrogenase- GFP; LmATG12, Leishmania major ATG12; mAPE1, mature form of vacuolar aminopeptidase 1; pAPE1, precursor form.

Original languageEnglish (US)
Pages (from-to)1540-1552
Number of pages13
JournalAutophagy
Volume9
Issue number10
DOIs
StatePublished - 2013

Fingerprint

Apicoplasts
Dihydrolipoamide Dehydrogenase
Aminopeptidases
Autophagy
Plasmodium falciparum
Fluorescence
Leishmania major
Glycine
Proteins
Genes

Keywords

  • Apicoplast
  • ATG8
  • Autophagy
  • Endosome
  • Food vacuole
  • Malaria
  • Plasmodium
  • RAB7

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Medicine(all)

Cite this

Tomlins, A. M., Ben-Rached, F., Williams, R. AM., Proto, W. R., Coppens, I., Ruch, U., ... Langsley, G. (2013). Plasmodium falciparum ATG8 implicated in both autophagy and apicoplast formation. Autophagy, 9(10), 1540-1552. https://doi.org/10.4161/auto.25832

Plasmodium falciparum ATG8 implicated in both autophagy and apicoplast formation. / Tomlins, Andrew M.; Ben-Rached, Fathia; Williams, Roderick AM; Proto, William R.; Coppens, Isabelle; Ruch, Ulrike; Gilberger, Tim W.; Coombs, Graham H.; Mottram, Jeremy C.; Müller, Sylke; Langsley, Gordon.

In: Autophagy, Vol. 9, No. 10, 2013, p. 1540-1552.

Research output: Contribution to journalArticle

Tomlins, AM, Ben-Rached, F, Williams, RAM, Proto, WR, Coppens, I, Ruch, U, Gilberger, TW, Coombs, GH, Mottram, JC, Müller, S & Langsley, G 2013, 'Plasmodium falciparum ATG8 implicated in both autophagy and apicoplast formation', Autophagy, vol. 9, no. 10, pp. 1540-1552. https://doi.org/10.4161/auto.25832
Tomlins AM, Ben-Rached F, Williams RAM, Proto WR, Coppens I, Ruch U et al. Plasmodium falciparum ATG8 implicated in both autophagy and apicoplast formation. Autophagy. 2013;9(10):1540-1552. https://doi.org/10.4161/auto.25832
Tomlins, Andrew M. ; Ben-Rached, Fathia ; Williams, Roderick AM ; Proto, William R. ; Coppens, Isabelle ; Ruch, Ulrike ; Gilberger, Tim W. ; Coombs, Graham H. ; Mottram, Jeremy C. ; Müller, Sylke ; Langsley, Gordon. / Plasmodium falciparum ATG8 implicated in both autophagy and apicoplast formation. In: Autophagy. 2013 ; Vol. 9, No. 10. pp. 1540-1552.
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