Plasmodium falciparum ATG8 implicated in both autophagy and apicoplast formation

Andrew M. Tomlins, Fathia Ben-Rached, Roderick AM Williams, William R. Proto, Isabelle Coppens, Ulrike Ruch, Tim W. Gilberger, Graham H. Coombs, Jeremy C. Mottram, Sylke Müller, Gordon Langsley

Research output: Contribution to journalArticlepeer-review

Abstract

APE1, vacuolar aminopeptidase 1; ATG, autophagy-related (gene); ATG, autophagy-related (protein); ATG8-I, ATG4-cleaved form of ATG8; ATG8-II, lipidated form of ATG8; CDS, coding sequence; GFP, green fluorescence protein; IPP, isopentenyl-pyrophosphate; mCherry, mCherry fluorescence protein; PE, phosphatidylethanolamine; PfATG8, Plasmodium falciparum ATG8; PfATG8?G, PfATG8 lacking the C-terminal glycine residue; PfATG3, P. falciparum ATG3; aLipDH-GFP, apicoplast lipoamide dehydrogenase-GFP; mLipDH-GFP, mitochondrial lipoamide dehydrogenase- GFP; LmATG12, Leishmania major ATG12; mAPE1, mature form of vacuolar aminopeptidase 1; pAPE1, precursor form.

Original languageEnglish (US)
Pages (from-to)1540-1552
Number of pages13
JournalAutophagy
Volume9
Issue number10
DOIs
StatePublished - Oct 2013

Keywords

  • ATG8
  • Apicoplast
  • Autophagy
  • Endosome
  • Food vacuole
  • Malaria
  • Plasmodium
  • RAB7

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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