PLASMID-MEDIATED RESISTANCE TO NALIDIXIC ACID IN SHIGELLA DYSENTERIAE TYPE 1

M. H. Munshi, Khaleda Haider, M. M. Rahaman, David A. Sack, Zia U. Ahmed, M. G. Morshed

Research output: Contribution to journalArticle

Abstract

In an epidemic of shigellosis in southern Bangladesh the causal organism, Shigella dysenteriae type 1, was resistant to nalidixic acid as well as to co-trimoxazole (trimethoprimsulphamethoxazole) and ampicillin. The genes coding for resistance to nalidixic acid, but not those coding for resistance to co-trimoxazole or ampicillin, are located on a conjugative 20 megadalton plasmid. This epidemic is of particular importance because of the resistance to nalidixic acid, an antibiotic to which shigellae are seldom resistant, and because plasmids were previously thought not to mediate resistance to nalidixic acid.

Original languageEnglish (US)
Pages (from-to)419-421
Number of pages3
JournalThe Lancet
Volume330
Issue number8556
DOIs
StatePublished - Aug 22 1987

ASJC Scopus subject areas

  • Medicine(all)

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    Munshi, M. H., Haider, K., Rahaman, M. M., Sack, D. A., Ahmed, Z. U., & Morshed, M. G. (1987). PLASMID-MEDIATED RESISTANCE TO NALIDIXIC ACID IN SHIGELLA DYSENTERIAE TYPE 1. The Lancet, 330(8556), 419-421. https://doi.org/10.1016/S0140-6736(87)90957-3