Plasmapheresis for the treatment of repeated early pregnancy wastage associated with anti-P

John A. Rock, Rosetta S. Shirey, Hayden G. Braine, Paul M. Ness, Thomas S. Kickler, Jennifer R. Niebyl

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It has been proposed that the blood group antibody, anti-P, produced by p or Pk individuals may cause abortion early in pregnancy. The authors have studied and successfully treated a Pkwoman with anti-P who had 13 consecutive firsttrimester miscarriages. Anti-P was implicated as the cause of repeated pregnancy loss after extensive clinical, endocrinologic, immunologic, and chromosomal evaluations. To remove P blood group antibodies, plasmapheresis was begun at five weeks' gestation during the 14th pregnancy with one plasma volume exchange two to three times per week. This therapy resulted in a reduction in the titer of anti-P, and the patient was delivered of a viable female infant after 33 weeks' gestation. The management and outcome indicate that habitual abortion presumably due to anti-P can be successfully treated with plasmapheresis. This case provides additional evidence that anti-P is responsible for abortions in p or Pk women, and that these abortions are immunologically mediated. 1985 The American College of Obstetricians and Gynecologists.

Original languageEnglish (US)
Pages (from-to)57S-60S
JournalObstetrics and gynecology
Issue number3
StatePublished - Sep 1985

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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