Plasma thrombomodulin levels in women with systemic lupus erythematosus

C. D. Hsu, Daniel Wan-Yui Chan, B. Iriye, T. R B Johnson, S. F. Hong, Michelle Petri

Research output: Contribution to journalArticle

Abstract

Thrombomodulin (TM), an endothelial cell membrane glycoprotein, is released into blood as a soluble TM antigen after inflammation or injury to endothelium. Systemic lupus erythematosus (SLE) is characterized by multisystem inflammation of vascular endothelium. The objective of this study is to determine the circulating TM levels in pregnant and nonpregnant SLE women and the correlation of plasma TM levels with variables used to assess SLE activity. We found that there were no significant differences in plasma TM levels among pregnant SLE, nonpregnant SLE, and normal pregnant patients. However, significantly higher plasma TM levels were found in some SLE women with active disease or preeclampsia.

Original languageEnglish (US)
Pages (from-to)27-29
Number of pages3
JournalAmerican Journal of Perinatology
Volume12
Issue number1
StatePublished - 1995

Fingerprint

Thrombomodulin
Systemic Lupus Erythematosus
Inflammation
Membrane Glycoproteins
Vascular Endothelium
Pre-Eclampsia
Endothelium
Endothelial Cells
Cell Membrane
Antigens
Wounds and Injuries

Keywords

  • endothelial damage
  • systemic lupus erythematosus
  • Thrombomodulin

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Pediatrics, Perinatology, and Child Health

Cite this

Plasma thrombomodulin levels in women with systemic lupus erythematosus. / Hsu, C. D.; Chan, Daniel Wan-Yui; Iriye, B.; Johnson, T. R B; Hong, S. F.; Petri, Michelle.

In: American Journal of Perinatology, Vol. 12, No. 1, 1995, p. 27-29.

Research output: Contribution to journalArticle

Hsu, C. D. ; Chan, Daniel Wan-Yui ; Iriye, B. ; Johnson, T. R B ; Hong, S. F. ; Petri, Michelle. / Plasma thrombomodulin levels in women with systemic lupus erythematosus. In: American Journal of Perinatology. 1995 ; Vol. 12, No. 1. pp. 27-29.
@article{886594f41a4240f7bae1e5014461d643,
title = "Plasma thrombomodulin levels in women with systemic lupus erythematosus",
abstract = "Thrombomodulin (TM), an endothelial cell membrane glycoprotein, is released into blood as a soluble TM antigen after inflammation or injury to endothelium. Systemic lupus erythematosus (SLE) is characterized by multisystem inflammation of vascular endothelium. The objective of this study is to determine the circulating TM levels in pregnant and nonpregnant SLE women and the correlation of plasma TM levels with variables used to assess SLE activity. We found that there were no significant differences in plasma TM levels among pregnant SLE, nonpregnant SLE, and normal pregnant patients. However, significantly higher plasma TM levels were found in some SLE women with active disease or preeclampsia.",
keywords = "endothelial damage, systemic lupus erythematosus, Thrombomodulin",
author = "Hsu, {C. D.} and Chan, {Daniel Wan-Yui} and B. Iriye and Johnson, {T. R B} and Hong, {S. F.} and Michelle Petri",
year = "1995",
language = "English (US)",
volume = "12",
pages = "27--29",
journal = "American Journal of Perinatology",
issn = "0735-1631",
publisher = "Thieme Medical Publishers",
number = "1",

}

TY - JOUR

T1 - Plasma thrombomodulin levels in women with systemic lupus erythematosus

AU - Hsu, C. D.

AU - Chan, Daniel Wan-Yui

AU - Iriye, B.

AU - Johnson, T. R B

AU - Hong, S. F.

AU - Petri, Michelle

PY - 1995

Y1 - 1995

N2 - Thrombomodulin (TM), an endothelial cell membrane glycoprotein, is released into blood as a soluble TM antigen after inflammation or injury to endothelium. Systemic lupus erythematosus (SLE) is characterized by multisystem inflammation of vascular endothelium. The objective of this study is to determine the circulating TM levels in pregnant and nonpregnant SLE women and the correlation of plasma TM levels with variables used to assess SLE activity. We found that there were no significant differences in plasma TM levels among pregnant SLE, nonpregnant SLE, and normal pregnant patients. However, significantly higher plasma TM levels were found in some SLE women with active disease or preeclampsia.

AB - Thrombomodulin (TM), an endothelial cell membrane glycoprotein, is released into blood as a soluble TM antigen after inflammation or injury to endothelium. Systemic lupus erythematosus (SLE) is characterized by multisystem inflammation of vascular endothelium. The objective of this study is to determine the circulating TM levels in pregnant and nonpregnant SLE women and the correlation of plasma TM levels with variables used to assess SLE activity. We found that there were no significant differences in plasma TM levels among pregnant SLE, nonpregnant SLE, and normal pregnant patients. However, significantly higher plasma TM levels were found in some SLE women with active disease or preeclampsia.

KW - endothelial damage

KW - systemic lupus erythematosus

KW - Thrombomodulin

UR - http://www.scopus.com/inward/record.url?scp=0028869413&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028869413&partnerID=8YFLogxK

M3 - Article

VL - 12

SP - 27

EP - 29

JO - American Journal of Perinatology

JF - American Journal of Perinatology

SN - 0735-1631

IS - 1

ER -