Abstract
Purpose: This study was designed to examine changes in peripheral plasma substance-P and -K levels, their association with follicle-stimulating hormone and luteinizing hormone release in normal reproductive cycles in humans, and their correlation with plasma estradiol and progesterone. Methods: Fourteen healthy, normally, menstruating women underwent daily blood sampling (cycle day 4, 4-14 days) for measurement of estradiol, progesterone, luteinizing hormone, and follicle-stimulating hormone, substances-P and -K, and daily transvaginal ultrasounds assessing follicular growth and documentation of ovulation. Results: Estradiol peaked on day 13, luteinizing hormone and follicle-stimulating hormone peaked on day 14, and progesterone began an exponential increase on about day 13. Conclusions: In contrast to other experimental designs using in vitro or in vivo rat or monkey tissue, peripheral levels of substances-P (P = 0.8391) and -K (P = 0.3205) reflected no modulation related to midcycle gonadotropin release in cycling woman.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 547-551 |
| Number of pages | 5 |
| Journal | Journal of Assisted Reproduction and Genetics |
| Volume | 15 |
| Issue number | 9 |
| State | Published - 1998 |
| Externally published | Yes |
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Keywords
- Gonadotropin surge
- Substance-K
- Substance-P
ASJC Scopus subject areas
- Obstetrics and Gynecology
- Developmental Biology
- Genetics
- Reproductive Medicine
Cite this
Plasma substance-P and substance-K and gonadal steroids in relation to the gonadotropin surge in normal human reproductive cycles. / Mohyi, D. L.; Kerdelhué, B.; Lenoir, V.; Kolm, P.; Jones, H. W.; Jones, G. S.
In: Journal of Assisted Reproduction and Genetics, Vol. 15, No. 9, 1998, p. 547-551.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Plasma substance-P and substance-K and gonadal steroids in relation to the gonadotropin surge in normal human reproductive cycles
AU - Mohyi, D. L.
AU - Kerdelhué, B.
AU - Lenoir, V.
AU - Kolm, P.
AU - Jones, H. W.
AU - Jones, G. S.
PY - 1998
Y1 - 1998
N2 - Purpose: This study was designed to examine changes in peripheral plasma substance-P and -K levels, their association with follicle-stimulating hormone and luteinizing hormone release in normal reproductive cycles in humans, and their correlation with plasma estradiol and progesterone. Methods: Fourteen healthy, normally, menstruating women underwent daily blood sampling (cycle day 4, 4-14 days) for measurement of estradiol, progesterone, luteinizing hormone, and follicle-stimulating hormone, substances-P and -K, and daily transvaginal ultrasounds assessing follicular growth and documentation of ovulation. Results: Estradiol peaked on day 13, luteinizing hormone and follicle-stimulating hormone peaked on day 14, and progesterone began an exponential increase on about day 13. Conclusions: In contrast to other experimental designs using in vitro or in vivo rat or monkey tissue, peripheral levels of substances-P (P = 0.8391) and -K (P = 0.3205) reflected no modulation related to midcycle gonadotropin release in cycling woman.
AB - Purpose: This study was designed to examine changes in peripheral plasma substance-P and -K levels, their association with follicle-stimulating hormone and luteinizing hormone release in normal reproductive cycles in humans, and their correlation with plasma estradiol and progesterone. Methods: Fourteen healthy, normally, menstruating women underwent daily blood sampling (cycle day 4, 4-14 days) for measurement of estradiol, progesterone, luteinizing hormone, and follicle-stimulating hormone, substances-P and -K, and daily transvaginal ultrasounds assessing follicular growth and documentation of ovulation. Results: Estradiol peaked on day 13, luteinizing hormone and follicle-stimulating hormone peaked on day 14, and progesterone began an exponential increase on about day 13. Conclusions: In contrast to other experimental designs using in vitro or in vivo rat or monkey tissue, peripheral levels of substances-P (P = 0.8391) and -K (P = 0.3205) reflected no modulation related to midcycle gonadotropin release in cycling woman.
KW - Gonadotropin surge
KW - Substance-K
KW - Substance-P
UR - http://www.scopus.com/inward/record.url?scp=0031734011&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031734011&partnerID=8YFLogxK
M3 - Article
C2 - 9822983
AN - SCOPUS:0031734011
VL - 15
SP - 547
EP - 551
JO - Journal of Assisted Reproduction and Genetics
JF - Journal of Assisted Reproduction and Genetics
SN - 1058-0468
IS - 9
ER -