Plasma substance-P and substance-K and gonadal steroids in relation to the gonadotropin surge in normal human reproductive cycles

D. L. Mohyi, B. Kerdelhué, V. Lenoir, P. Kolm, H. W. Jones, G. S. Jones

Research output: Contribution to journalArticle

Abstract

Purpose: This study was designed to examine changes in peripheral plasma substance-P and -K levels, their association with follicle-stimulating hormone and luteinizing hormone release in normal reproductive cycles in humans, and their correlation with plasma estradiol and progesterone. Methods: Fourteen healthy, normally, menstruating women underwent daily blood sampling (cycle day 4, 4-14 days) for measurement of estradiol, progesterone, luteinizing hormone, and follicle-stimulating hormone, substances-P and -K, and daily transvaginal ultrasounds assessing follicular growth and documentation of ovulation. Results: Estradiol peaked on day 13, luteinizing hormone and follicle-stimulating hormone peaked on day 14, and progesterone began an exponential increase on about day 13. Conclusions: In contrast to other experimental designs using in vitro or in vivo rat or monkey tissue, peripheral levels of substances-P (P = 0.8391) and -K (P = 0.3205) reflected no modulation related to midcycle gonadotropin release in cycling woman.

Original languageEnglish (US)
Pages (from-to)547-551
Number of pages5
JournalJournal of Assisted Reproduction and Genetics
Volume15
Issue number9
DOIs
StatePublished - Jan 1 1998

Keywords

  • Gonadotropin surge
  • Substance-K
  • Substance-P

ASJC Scopus subject areas

  • Reproductive Medicine
  • Genetics
  • Obstetrics and Gynecology
  • Developmental Biology
  • Genetics(clinical)

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