Plasma selenium levels and oxidative stress biomarkers: A gene-environment interaction population-based study

Inmaculada Galan-Chilet, Maria Tellez-Plaza, Eliseo Guallar, Griselda De Marco, Raul Lopez-Izquierdo, Isabel Gonzalez-Manzano, M. Carmen Tormos, Gracia M. Martin-Nuñez, Gemma Rojo-Martinez, Guillermo T. Saez, Juan C. Martín-Escudero, Josep Redon, F. Javier Chaves

Research output: Contribution to journalArticle

Abstract

The role of selenium exposure in preventing chronic disease is controversial, especially in selenium-repleted populations. At high concentrations, selenium exposure may increase oxidative stress. Studies evaluating the interaction of genetic variation in genes involved in oxidative stress pathways and selenium are scarce. We evaluated the cross-sectional association of plasma selenium concentrations with oxidative stress levels, measured as oxidized to reduced glutathione ratio (GSSG/GSH), malondialdehyde (MDA), and 8-oxo-7,8-dihydroguanine (8-oxo-dG) in urine, and the interacting role of genetic variation in oxidative stress candidate genes, in a representative sample of 1445 men and women aged 18-85 years from Spain. The geometric mean of plasma selenium levels in the study sample was 84.76 μg/L. In fully adjusted models the geometric mean ratios for oxidative stress biomarker levels comparing the highest to the lowest quintiles of plasma selenium levels were 0.61 (0.50-0.76) for GSSG/GSH, 0.89 (0.79-1.00) for MDA, and 1.06 (0.96-1.18) for 8-oxo-dG. We observed nonlinear dose-responses of selenium exposure and oxidative stress biomarkers, with plasma selenium concentrations above ~110 μg/L being positively associated with 8-oxo-dG, but inversely associated with GSSG/GSH and MDA. In addition, we identified potential risk genotypes associated with increased levels of oxidative stress markers with high selenium levels. Our findings support that high selenium levels increase oxidative stress in some biological processes. More studies are needed to disentangle the complexity of selenium biology and the relevance of potential gene-selenium interactions in relation to health outcomes in human populations.

Original languageEnglish (US)
Pages (from-to)229-236
Number of pages8
JournalFree Radical Biology and Medicine
Volume74
DOIs
StatePublished - Sep 2014

Keywords

  • Gene-environment interaction
  • Oxidative stress
  • Population based
  • Selenium

ASJC Scopus subject areas

  • Biochemistry
  • Physiology (medical)

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    Galan-Chilet, I., Tellez-Plaza, M., Guallar, E., De Marco, G., Lopez-Izquierdo, R., Gonzalez-Manzano, I., Carmen Tormos, M., Martin-Nuñez, G. M., Rojo-Martinez, G., Saez, G. T., Martín-Escudero, J. C., Redon, J., & Javier Chaves, F. (2014). Plasma selenium levels and oxidative stress biomarkers: A gene-environment interaction population-based study. Free Radical Biology and Medicine, 74, 229-236. https://doi.org/10.1016/j.freeradbiomed.2014.07.005